Formula C25H40N7O19P3S | Molar mass 867.608 g/mol | |
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Methylmalonyl-CoA is the thioester consisting of coenzyme A linked to methylmalonic acid. It is an important intermediate in the biosynthesis of many organic compounds as well as in the process of carbon assimilation.
Biosynthesis and conversions
Methylmalonyl-CoA is formed from propionyl-CoA by propionyl-CoA carboxylase by help of biotin (vitamin B7). It is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B12 as a cofactor. In this way, it enters the Krebs cycle. The following diagram demonstrates the aforementioned reactions:
Propionyl CoA → Methylmalonyl CoA → Succinyl CoAReferences
Methylmalonyl-CoA Wikipedia(Text) CC BY-SA