Medina is a habitational surname name from any of the several places, so called from the city of Medina in Saudi Arabia. Medina means "city" in Arabic. The surname is also borne by Sephardic Jews.
Alberto Medina Briseño (born 1983), Mexican footballer
Alexander Medina Reobasco (born 1978), Uruguayan footballer
Anabel Medina Garrigues (born 1982), Spanish tennis player
Ann Medina, Canadian award-winning journalist
Antonio Medina (disambiguation), multiple people
Avihu Medina (born 1948), Israeli singer-songwriter
Benny Medina (born 1958), African-American music producer, talent manager and record executive
Biel Medina Piris (born 1980), Spanish footballer
César Medina Lozado (born 1991), Peruvian footballer
Chris Medina (born 1983), American singer and American Idol contestant
Claribel Medina (born 1961), Puerto Rican actress
Danilo Medina Sánchez (born 1951), Dominican politician and President of the Dominican Republic since 2012
David M. Medina (born 1958), a former Justice of the Texas Supreme Court
Debra Medina (born 1962), 2010 Texas gubernatorial candidate
Ernest Medina (born 1936), US Army captain who was the commanding officer of the unit responsible for the My Lai Massacre
Fernando Medina (born 1973), Portuguese politician and mayor of Lisbon
Fernando Medina (born 1973), Spanish fencer
Henrique Medina (1901–1988), 20th century Portuguese painter
Humberto Medina (dancer), Cuban dancer
Humberto Medina (footballer) (1942–2011), Mexican footballer
Isaías Medina Angarita (1897-1953), Venezuelan militar. President of Venezuela(1941-1945)
Iizzwa Medina (born 1982), Honduran retired table tennis player
John Baptist Medina (1659 – 1710), artist of Flemish-Spanish origin who worked in England and Scotland
Jorge Medina (born 1926), Chilean cardinal of the Catholic Church
José Medina (disambiguation)
Juan Medina (disambiguation)
Julio Medina III (born 1976), Panamanian footballer
Leonardo Medina Gutiérrez (born 1977), Uruguayan footballer
Lina Medina (born 1933), youngest mother in recorded history
Luis Medina (disambiguation)
Luiz Carlos Medina (born 1990), Brazilian footballer
Maria Medina (1769—1821 or 1833), ballet dancer, the wife of choreographer Salvatore Viganò
Nery Medina Norales (born 1981), Honduran footballer
Nicolás Medina (born 1982), Argentine footballer
Nicolás Esteban Medina Ríos (born 1987), Chilean footballer
Ninrrol Medina Torres (born 1976), Honduran retired footballer and current manager
Ofelia Medina (born 1950), Mexican actress
Patricia Medina (1919–2012), English actress
Paula Medina (born 1989), Colombian table tennis player
Pol Medina, Jr. (born 1960), Filipino comics artist
Rafael Medina Rodríguez (born 1979), Mexican professional footballer
Rafael Medina (baseball) (born 1975), Panamanian former Major League Baseball pitcher
Ricardo Medina, Jr. (born 1979), American actor
Salvador Medina Cárcamo (born 1988), Mexican footballer
Stefan Medina Ramírez (born 1992), Colombian footballer
Tulia Angela Medina, Colombian weightlifter
Wilder Medina Tamayo (born 1981), Colombian footballer
Yoervis Medina (born 1988), Venezuelan Major League Baseball pitcher
Yojer Medina (born 1973), Venezuelan shot putter and discus thrower