ATC code N06BX01 (WHO) PubChem CID 4039 UNII C76QQ2I0RG Classification Glycolates | CAS Number 51-68-3 ChemSpider 3899 CAS ID 51-68-3 | |
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AHFS/Drugs.com International Drug Names | ||
Meclofenoxate (INN, BAN) (brand name Lucidril), also known as centrophenoxine, is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).
Contents
In elderly patients, meclofenoxate has been found clinically to improve memory, have a mentally stimulating effect, and improve general cognition. Meclofenoxate also increases cellular membrane phospholipids. Although meclofenoxate is generally considered to be a dietary supplement, in some European countries, such as Germany, Hungary, and Austria, as well as Japan, it is a prescription drug.
Side effects
Meclofenoxate is considered to be very safe and high in tolerability. However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.
Research
Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 30–50%, and thus may be anti-aging drugs/supplements.
Brand names
In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.