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Manuel Morales

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Citizenship
  
USA

Nationality
  
Honduran

Name
  
Manuel Morales


Manuel Morales Manuel Morales manolomoralesr Twitter

Born
  
July 23, 1919 San Pedro, Sula, Honduras (
1919-07-23
)

Died
  
November 12, 2009(2009-11-12) (aged 90)

Fields
  
Biophysics, Cell biology

Institutions
  
University of Chicago, Naval Medical Research Institute, Dartmouth Medical School, UCSF, University of the Pacific

Alma mater
  
UC Berkeley A.B., Harvard University Ph.D

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Manuel Francisco Morales (July 23, 1919 – November 12, 2009) was a Honduran-born American biophysicist who did pivotal research on the molecular basis of muscle contraction.

Contents

Juan manuel morales


Scientific career

In the 1950s at the Naval Medical Research Institute, Morales and Terrell Hill showed that the high energy of the terminal phosphate bond in ATP was due to electrostatic repulsion between the three phosphate groups, and he and Richard Podolsky measured the heat of hydrolysis for ATP cleavage, the fundamental energy currency of biological metabolism.

Awards and service

Morales was elected a member of the US National Academy of Sciences and awarded the Order of the Rising Sun (Japan). He served as President of the Biophysical Society for 1968–69, and was the founding editor of the Annual Review of Biophysics.

Key publications

  • Hill TL, Morales MF. (1951) On “High Energy Phosphate Bonds” of Biochemical Interest. Journal of the American Chemical Society 73: 1656–1660 (doi:10.1021/ja01148a072)
  • Podolsky RJ, Morales MF. (1956) The Enthalpy Change of Adenosine Triphosphate Hydrolysis Journal of Biological Chemistry 218: 945–959 (pdf)
  • Mendelson RA, Morales MF, Botts J. (1973) Segmental flexibility of the S-1 moiety of myosin. Biochemistry 12: 2250–2255 (doi:10.1021/bi00736a011)
  • Morales MF, Botts J. (1979) On the molecular basis for chemomechanical energy transduction in muscle. Proceedings of the National Academy of Sciences USA 76: 3857–3859
  • Botts J, Takashi R, Torgerson P, Hozumi T, Muhlrad A, D Mornet D, Morales MF. (1984) On the mechanism of energy transduction in myosin subfragment 1. Proceedings of the National Academy of Sciences USA 81: 2060–2064
  • Botts J, Thomason JF, Morales MF. (1989) On the origin and transmission of force in actomyosin subfragment 1. Proceedings of the National Academy of Sciences USA 86: 2204–2208
  • Onishi H, Mochizuki N, Morales MF. (2004) On the Myosin Catalysis of ATP Hydrolysis. Biochemistry 43: 3757–3763 (doi:10.1021/bi040002m)

    • References

    Manuel Morales Wikipedia
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