Species Human Entrez 4335 | Human Mouse Ensembl ENSG00000070444 | |
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Aliases MNT, MAD6, MXD6, ROX, bHLHd3, MAX network transcriptional repressor External IDs MGI: 109150 HomoloGene: 7842 GeneCards: MNT | ||
Max-binding protein MNT is a protein that in humans is encoded by the MNT gene.
Contents
Function
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.
Interactions
MNT (gene) has been shown to interact with MLX, SIN3A and MAX.