Samiksha Jaiswal (Editor)

ML domain

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Symbol
  
E1_DerP2_DerF2

InterPro
  
IPR003172

SUPERFAMILY
  
1a9v

Pfam
  
PF02221

SCOP
  
1a9v

OPM protein
  
1nep

ML domain

The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of immunoglobulin E-set domains. This domain is present in the following proteins:

  • Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes.
  • House dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus.

    • Human proteins containing this domain

    LY86; LY96; MMD-1;

    References

    ML domain Wikipedia
    (Text) CC BY-SA