Species Human Entrez 5595 | Human Mouse Ensembl ENSG00000102882 | |
 | ||
Aliases MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3 External IDs OMIM: 601795 MGI: 1346859 HomoloGene: 55682 GeneCards: MAPK3 | ||
Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene.
Contents
Function
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
Clinical significance
It has been suggested that MAPK3, along with the gene IRAK1, is turned off by two microRNAs that were activated after the influenza A virus had been made to infect human lung cells.
Interactions
MAPK3 has been shown to interact with: