Species Human Entrez 4760 | Human Mouse Ensembl ENSG00000162992 | |
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Aliases NEUROD1, BETA2, BHF-1, MODY6, NEUROD, bHLHa3, neuronal differentiation 1 External IDs MGI: 1339708 HomoloGene: 1871 GeneCards: NEUROD1 | ||
Neurogenic differentiation 1 (NeuroD1), also called β2, is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.
It is a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
Interactions
NEUROD1 has been shown to interact with MAP3K10, MAFA and Cyclin D1.
References
NEUROD1 Wikipedia(Text) CC BY-SA