Species Human Entrez 8379 | Human Mouse Ensembl ENSG00000002822 | |
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Aliases MAD1L1, PIG9, TP53I9, TXBP181, MAD1, MAD1 mitotic arrest deficient like 1 External IDs OMIM: 602686 MGI: 1341857 HomoloGene: 74500 GeneCards: MAD1L1 | ||
Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.
Contents
MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes.
Function
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
Interactions
MAD1L1 has been shown to interact with:
References
MAD1L1 Wikipedia(Text) CC BY-SA