He was born in a village named Thagattur in Vedaranyam Taluk, Nagapattinam District. He is the elder son of the family. His immediate family is short, his wife named M.Latha, Daughter M.Radha and Son M.Srinivasan. His family was lived at his native village Thagattur until 1991. In 1991, he temporarily relocated his family to nearby town Thiruthuraipoondi, Thiruvarur District for his children's school education and then to Tiruchirappalli for their higher education in 2001. He is a deep follower of Hinduism.
M. S. Manickam completed his graduation and post-graduation in Arts from Alagappa Government Arts College, Karaikudi in Alagappa University and Pachaiyappa's College, Chennai Madras University.
M. S. Manickam was an agriculturist by profession.
M. S. Manickam involved partially in business activities.
M. S. Manickam entered politics during his college life, inspired by M. G. Ramachandran acting in Tamil films and election campaign for DMK, and involved in MGR's charity activities organized by their fans in college. He joined M.G.Ramachandran's new party Anna Dravida Munnetra Kazhagam (ADMK) in 1972 along with his college seniors and mentors who are very active in MGR charities.
Member of the Legislative Assembly
M. S. Manickam contested as Anna Dravida Munnetra Kazhagam candidate for the first time (after MGR's split from DMK in 1972) to the Tamil Nadu legislative assembly in 1977 at the age of 30, but lost to M. Meenakshi Sundaram (DMK candidate) and came to the third position while congress candidate took the second spot.
He was elected to the Tamil Nadu legislative assembly as an Anna Dravida Munnetra Kazhagamcandidate from Vedaranyam constituency in the 1980 election at the age of 33. He worked hard for the people during his tenure between 1980-1984.
Exit from ADMK
After MGR's death in 1987 and new ADMK party head's takeover changed the scenario of M. S. Manickam political activities. In 1995, he left the All India Anna Dravida Munnetra Kazhagam (AIADMK) as there was not given enough opportunity to him to serve for the people in that party.
After leaving ADMK in 1995 he was little active in politics with MGR Kazhagam formed by R. M. Veerappan and then later he gradually given his way to new comers who are looking energetic in politics to do good for the society by supporting them in Assembly Elections Win and as their mentor.
Later in 2010 he was defected to the Thai Kazhagam (Mother Party) Dravida Munnetra Kazhagam along with few Ex. MLAs and Ex. Minister Alagu.Thirunavukkarasu, thought to come back in active politics to do something left in him for the people.
Suffering from sudden heart pain in the early morning, he was admitted to the Apollo Hospital in Chennai on 14 December 2010 afternoon. He died due to Heart Attack at the age of 64 on the same day night 9:31 at Appollo Hospital. On his funeral, the next day was attended by thousands of public, relatives, family members and local politicians from all the parties. His son, Srinivasan performed his last rites at the Crematorium, Thagattur, Vedaranyam Taluk.