Lucio is an Italian, Spanish, male given name derived from the Latin name Lucius. In Portuguese, the given name is accented Lúcio

Lucio is also an Italian surname.

"Lúcio", (Lucimar Ferreira da Silva) (born 1978), Brazilian footballerEduardo Lúcio Esteves Pereira (born 1954), Portuguese goalkeeper, an earlier football "Lúcio"Lucio Amanti (born 1977), Canadian cellistLucio Battisti (1943–1998), Italian singer-songwriterLucio Blanco (1879–1922), Mexican military officerLúcio Carlos Cajueiro Souza (born 1979), Brazilian footballerLúcio Costa (1902–1998), Brazilian architect and urban plannerLucio Dalla (1943–2012), Italian singer-songwriterLúcio Teófilo da Silva (born 1984), Brazilian football playerLucio Diodati (born 1955), Italian painterLucio Fontana (1899–1968), Italian painter and sculptorLucio Fulci (1927–1996), Italian horror film directorLucio Gutiérrez (born 1957), President of Ecuador from 2003–2005Lucio Serrani (born 1961), Italian hammer throwerLúcio Soares (1934–1988), Portuguese footballerLucio Urtubia (born 1931), Spanish anarchistLúcio Cardoso (1812–1968), Brazilian writerLúcio Wagner (born 1976), Bulgarian footballer
Francisco Andres Lucio (born 1973), American record producer, singer-songwriter, musician and DJShannon Lucio (born 1980), American actressHanibal Lucić (1485–1553) known in Italian as Annibale Lucio, Croatian language poet and playwright from Venetian DalmatiaJohannes Lucius Croatian: Ivan Lučić, Italian: Giovanni Lucio (1604–1679) historianLucius Accius (170 – c. 86 BC), Roman tragic poetLucius Annaeus Seneca (c. 4 BC – AD 65), Roman philosopher
Lúcio (Overwatch), a character in the 2016 video gameLucio, a minor character in Shakespeare's Measure for Measure