Louis is a surname. Notable people with the surname include:
Antoine Louis (1723–1792), French surgeon and physiologist
Arthur Louis (1945–2014), British musician
Errol Louis (born 1962), American journalist and television show host
Chris Louis (born 1969), English speedway rider
Christos Louis (born 1948), Greek molecular geneticist
Godfrey Louis, solid-state physicist
Jean Louis (1907–1997), French-born costume designer
Jefferson Louis (born 1979), English footballer
Joe Louis (1914–1981), American heavyweight boxer
Julia Louis-Dreyfus (born 1961), American actress, comedian, and producer
Lance Louis (born 1985), American football player
Laurent Louis (born 1980), Belgian politician
Léopold Louis-Dreyfus (1833–1915), French businessman, founder of the Louis Dreyfus Group, and patriarch of the Louis-Dreyfus family
Lil Louis, stage name of American house-music producer and DJ Louis Sims
Michèle Pierre-Louis (born 1947), Haitian politician
Morris Louis (1912–1962), American painter
Murray Louis (born 1926), American modern dancer and choreographer
Pierre Charles Alexandre Louis (1787–1872), French physician
Séraphine Louis (1864–1942), French painter
Spyridon Louis (1873–1940), Greek runner
Thomas Louis (1758–1807), British naval officer
Tim Louis (born 1958), Canadian lawyer and municipal politician
Tristan Louis (born 1971), French-American author
William Roger Louis (born 1936), American historian
