CAS Number 100324-81-0 ChemSpider 438549 ChEMBL CHEMBL1411 | PubChem CID 501254 UNII L1F2Q2X956 Molar mass 280.32 g/mol | |
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Synonyms 1-(5-Hydroxyhexyl)-3,7-dimethylxanthine (HDX) | ||
Lisofylline (LSF) is a synthetic small molecule with novel anti-inflammatory properties. LSF can effectively prevent type 1 diabetes in preclinical models and improves the function and viability of isolated or transplanted pancreatic islets. It is a metabolite of pentoxifylline.
Contents
As well, LSF improves cellular mitochondrial function and blocks interleukin-12 (IL-12) signaling and STAT-4 activation in target cells and tissues. IL-12 and STAT-4 activation are important pathways linked to inflammation and autoimmune damage to insulin producing cells. Therefore, LSF and related analogs could provide a new therapeutic approach to prevent or reverse type 1 diabetes. LSF also directly reduces glucose-induced changes in human kidney cells suggesting that LSF and analogs have the potential to treat the complications associated with diabetes.
Pronounce medical words lisofylline
Synthesis
The R enantiomer of the pentoxyfylline analogue in which the ketone has been reduced to an alcohol shows enhanced activity as an inhibitor of acetyl CoA over the parent drug.
DE 3942872 ; eidem, U.S. Patent 5,310,666 (1991, 1994 both to Hoechst). Asymmetric synthesis: J. P. Klein et al., WO 9531450 (1995 to Cell Therapeutics).
For analogs see: