Samiksha Jaiswal (Editor)

Leukotriene A4 hydrolase

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EC number
  
3.3.2.6

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
90119-07-6

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

Leukotriene-A4 hydrolase

Leukotriene A4 hydrolase, also known as LTA4H is a human gene. The protein encoded by this gene is a bifunctional enzyme (EC 3.3.2.6) which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase.

Contents

Function

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase. Other names in common use include LTA4 hydrolase, LTA4H, and leukotriene A4 hydrolase. This enzyme participates in arachidonic acid metabolism.

Structure

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1GW6, 1H19, 1HS6, and 1SQM.

References

Leukotriene-A4 hydrolase Wikipedia


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