Species Human Entrez 4058 | Human Mouse Ensembl ENSG00000062524 | |
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Aliases LTK, TYK1, Leukocyte receptor tyrosine kinase External IDs MGI: 96840 HomoloGene: 130502 GeneCards: LTK | ||
Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.
Contents
Function
The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown. Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Interactions
LTK has been shown to interact with IRS-1, Shc, and PIK3R1.
References
Leukocyte receptor tyrosine kinase Wikipedia(Text) CC BY-SA