Entrez 9227 | Ensembl ENSG00000121207 | |
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Aliases LRAT, LCA14, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) External IDs MGI: 1891259 HomoloGene: 3483 GeneCards: LRAT | ||
Gene music using protein sequence of lrat lecithin retinol acyltransferase phosphatidylcholine r
Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.
Contents
- Gene music using protein sequence of lrat lecithin retinol acyltransferase phosphatidylcholine r
- Function
- Clinical significance
- References
Function
Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.
Clinical significance
Mutations in this gene have been associated with early-onset severe retinal dystrophy.
LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.
References
Lecithin retinol acyltransferase Wikipedia(Text) CC BY-SA