Trisha Shetty (Editor)

Lead compound

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Looking for a lead compound


A lead compound (i.e. a "leading" compound, not lead metal) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may still have suboptimal structure that requires modification to fit better to the target. Lead drugs are followed by back-up compounds. Its chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters. Furthermore, newly invented pharmacologically active moieties may have poor druglikeness and may require chemical modification to become drug-like enough to be tested biologically or clinically.

Contents

Lead compound Illustrated Glossary of Organic Chemistry Lead compound

Fsc chemistry book2 ch 3 lec 24 lead compounds in paints


Discovering lead compounds

Lead compound FileAn example of a lead compoundpng Wikimedia Commons

A lead compound may arise from a variety of different sources. Lead compounds are found by characterizing natural products, employing combinatorial chemistry, or by molecular modeling as in rational drug design. Lead compounds are often tested by high-throughput screenings (active compounds are designated as "hits") which can screen compounds for their ability to inhibit (antagonist) or stimulate (agonist) a receptor of interest as well as determine their selectivity for them.

Lead compound Drug designing and enzymology

Lead compound New Malaria Lead Compound Identified News ChemistryViews

References

Lead compound Wikipedia


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