Siegemund has won two singles title and three doubles titles on the WTA tour, as well as 11 singles and 20 doubles titles on the ITF circuit. On 29 August 2016, she reached her best singles ranking of world no. 27 and on 25 April 2016, she peaked at world no. 40 in the doubles rankings.
Siegemund was born to parents Harro (an engineer) and Brigitta Siegemund. She has two siblings. She was introduced to tennis by her family at age 3. Siegemund lived in Riyadh, Saudi Arabia from age 4 to 7 and in Jakarta, Indonesia from age 9 to 10. She is fluent in German, English, and French, and in 2016, she completed her bachelor's degree in Psychology from the University of Hagen. Her tennis idol growing up was Steffi Graf.
Siegemund won the Junior Orange Bowl in the "12 and under" age category as the first German since Steffi Graf in 1981.
2002: Siegemund played her first events of career on ITF Circuit.
2003: Siegemund played her first WTA qualifying in Leipzig, Germany.
2004: Siegemund continued to play on ITF Circuit.
2005: Siegemund won her first doubles title on ITF Circuit in Darmstadt, Germany.
2006: Siegemund won her first singles title on ITF Circuit in Lagos, Nigeria and three doubles titles on ITF Circuit, but fell in WTA singles qualifying twice.
2007: Siegemund won one doubles title on ITF Circuit, but fell in WTA singles qualifying once.
2008: Siegemund won three doubles title on ITF Circuit, but fell in WTA singles qualifying once.
2009: Siegemund won two doubles title on ITF Circuit, but fell in WTA singles qualifying once at the US Open.
2010: Siegemund played her first WTA main draw in Båstad, Sweden, falling in the first round as a qualifier. She won four doubles titles on ITF Circuit, but fell in WTA singles qualifying once.
2011: Siegemund won one singles title on ITF Circuit, but fell in WTA singles qualifying nine times (incl. Roland Garros, Wimbledon, US Open).
2012: Siegemund won three singles titles and one doubles title on ITF Circuit.
2013: Siegemund won three singles titles and two doubles titles on ITF Circuit, but fell in WTA singles qualifying once (US Open).
2014: Siegemund reached the second round in Båstad, losing to Chanelle Scheepers. She won two singles titles and two doubles titles on ITF Circuit, but fell in the first round once and in WTA singles qualifying four times (incl. Roland Garros, Wimbledon, US Open).
Siegemund got to the Top 100 in WTA ranking (finishing No. 90). She reached the quarterfinals at WTA Tour twice in Florianópolis, Brazil and in Kockelscheuer, Luxembourg. She reached the second round once; fell in the first round four times (incl. Wimbledon and US Open) and in qualifying five times (incl. the other two majors). In Wimbledon, she reached for her first time a Grand Slam main draw after exiting ten times in the qualification rounds. She won three WTA doubles titles and also won one singles title and one doubles title on ITF Circuit.
At the 2016 Australian Open, Siegemund scored one of the biggest victories of her career, defeating former world number one Jelena Janković in the second round in three sets.
In April, Siegemund made an upset by reaching the final as a qualifier in Stuttgart, Germany, losing to compatriot and defending champion Angelique Kerber. On her way to this success she beat three top-10 players in a row (Simona Halep, Roberta Vinci and Agnieszka Radwańska), all of them in straight sets.
At the Premier Mandatory tournament in Madrid Siegemund reached as a qualifier the third round. After beating ninth-seed Svetlana Kuznetsova and Mirjana Lučić-Baroni she lost to Sorana Cîrstea.
At the French Open and in Wimbledon Siegemund was knocked out in the first round.
In July, Siegemund won the first WTA Tour title of her career in Båstad, the place where she played her first WTA Tour match in 2010. In the final, she defeated Kateřina Siniaková in straight sets.
In September, Siegemund won her first Grand Slam title, winning the US Open mixed doubles championship with Mate Pavić.
Siegemund won her second career title in her hometown Premier event, the Porsche Tennis Grand Prix, defeating Kristina Mladenovic in the final in three sets. She had been awarded a wildcard entry into the event because of her low ranking.
In May, Siegemund suffered a knee injury at the Nuremberg Cup which kept her out for the rest of the season.
Overall Win–Loss: WTA Tour main draw (incl. Grand Slams), Olympics and Fed Cup
Current till 2017 Nuremberg.
Siegemund's match record against players who have been ranked in the top 10.
Siegemund has a 9–7 record against players who were, at the time the match was played, ranked in the top 10.