Species Human Entrez 23284 | Human Mouse Ensembl ENSG00000150471 | |
Aliases ADGRL3, CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3 External IDs MGI: 2441950 HomoloGene: 22878 GeneCards: ADGRL3 | ||
Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.
Contents
Function
This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.
Clinical significance
A version of this gene has been linked to Attention Deficit/Hyperactivity Disorder (ADHD).
References
Latrophilin 3 Wikipedia(Text) CC BY-SA