Routes of
administration Oral CAS Number 118288-08-7 ChemSpider 4445337 | ATC code A02BA08 (WHO) PubChem CID 5282136 | |
AHFS/Drugs.com International Drug Names | ||
Lafutidine (INN) is a second generation histamine H2 receptor antagonist having multimodal mechanism of action and used to treat gastrointestinal disorders. It is marketed in Japan and India.
Contents
Medical use
Lafutidine is used to treat gastric ulcers, duodenal ulcers, as well as wounds in the lining of the stomach associated with acute gastritis and acute exacerbation of chronic gastritis.
Adverse effects
Adverse events observed during clinical trials included constipation, diarrhea, drug rash, nausea, vomiting and dizziness.
Mechanism of action
Like other H2 receptor antagonists it prevents the secretion of gastric acid. It also activates calcitonin gene-related peptide, resulting in the stimulation of nitric oxide (NO) and regulation of gastric mucosal blood flow, increases somatostatin levels also resulting in less gastric acid secretion, causes the stomach lining to generate more mucin, inhibits neutrophil activation thus preventing injury from inflammation, and blocks the attachment of Helicobacter pylori to gastric cells.
Trade names
It is marketed in Japan as Stogar by UCB and in India as Lafaxid by Zuventus Healthcare.