Supriya Ghosh (Editor)

Laboratoires Servier

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Type
  
Private

Products
  
Pharmaceuticals

Headquarters
  
Neuilly-sur-Seine, France

Founded
  
1954

Industry
  
Pharmaceutical

Website
  
Official website

Founder
  
Jacques Servier

Number of employees
  
21,200


Revenue
  
3.9 billion EUR (Fiscal year)

CEO
  
Olivier Laureau (Apr 2014–)

Subsidiaries
  
Biogaran, S.A.S, Adir, Institut De Recherches Servier

Servier campus un stage chez les laboratoires servier


Servier Laboratories (French: Laboratoires Servier, often abbreviated to Servier) is a privately owned French pharmaceutical company that specialises in medication for cardiological and rheumatological conditions, as well as for diabetes and clinical depression. The consolidated turnover for the 2015 financial year was €3.9 billion. Servier is the leading French independent pharmaceutical company, and the second largest French pharmaceutical company worldwide. It has branches in 140 countries, achieving 82% of its sales outside France. The annual sales of its ACE inhibitor, Coversyl (perindopril), in 2006 and 2007 exceeded 1 billion US dollars, making it Servier's highest-selling product.

Contents

The company reportedly invests a little under 25% of its turnover in research and development, which occupies 3,000 of its 21,200 employees worldwide. The company's production sites produced 853 million drug boxes in 2013.

The Servier Clinical Support Unit in Gidy (near Orléans), which produces drugs for clinical trials, is the largest unit of its kind in Europe. Servier Laboratories is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA).

Mediator, an amphetamine-based Servier drug originally developed for weight loss in people with diabetes but often prescribed off-label as a dieting aid, was withdrawn from the market after being linked to 500–2000 deaths in France. Further investigations found that many previous safety alerts on that drug had been either missed or covered up, possibly through improper influence of the company.

Product portfolio

Notable products:

  • Gliclazide (Diamicron, Diamicron MR) — antidiabetic drug
  • Indapamide (Fludex SR, Natrilex SR, Lozide) — diuretic
  • Ivabradine (Procoralan) — antianginal drugs
  • Perindopril (Coversyl) — ACE inhibitor
  • Strontium ranelate (Protelos) — osteoporosis agent
  • Tianeptine (Stablon) — antidepressant, indirect alteration of AMPA and NMDA glutamate receptor activity
  • Trimetazidine (Vastarel MR) — antianginal drug.
  • Other products:

  • Agomelatine (Valdoxan, Melitor, Thymanax)
  • Almitrine (Duxil, Vectarion)
  • Amineptine (Survector, Maneon, Directim)
  • Benfluorex (Mediaxal)
  • Carbutamide (Glucidoral)
  • Daflon 500
  • Fenspiride (Pneumorel)
  • Fotemustine (Muphoran)
  • Fusafungine (Locabiotal)
  • Gliclazide (Diamicron)
  • Indapamide (Natrilix, Tertensif, Lozide)
  • Perindopril (Coversyl, Prestarium)
  • Perindopril/indapamide (Preterax, Coversyl Plus)
  • Piribedil (Trivastal retard)
  • Rilmenidine (Hyperium)
  • Sodium alginate (Pseudophage)
  • Sulbutiamine (Arcalion)
  • Tertatolol (Artex)
  • Vitamins (Vitathion)
  • Collaborative research

    As well as internal research and development activities, Servier undertakes publicly funded collaborative research projects with industrial and academic partners. One example, in the area of non-clinical safety assessment, is the InnoMed PredTox. The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative of EFPIA and the European Commission.

    In addition to these, Servier engages in research and licensing collaborations across the pharmaceutical and biotechnology industry. These collaborations include:

  • In Cardiology: XENTION (UK, 2013), AMGEN (USA, 2013), MIRAGEN (USA, 2011), ARMGO (USA, 2006)
  • In Diabetes: INTARCIA (USA, 2014)
  • In Metabolic diseases: INTERCEPT - TGR5 agonists (USA, 2011), GENFIT (FR, 2004)
  • In Neurology (MS): GENEURO (CH, 2014)
  • In Oncology: CTI BIOPHARMA (USA, 2014), NOVARTIS (CH, 2014), CELLECTIS (FR, 2014), NERVIANO (IT, 2013), EOS (IT) / CLOVIS (USA, 2012), BIOINVENT (SE, 2012), MACROGENICS (USA, 2011/12), GALAPAGOS (NDL, 2011), BIOREALITES (FR, 2011), PHARMACYCLICS - HDAC inhibitor (USA, 2009), HYBRIGENICS (FR, 2007/2011) VERNALIS (UK, 2007/2011)
  • In Orphan Diseases/Cardiology/Diabetes: XOMA (USA, 2010)
  • In Osteoporosis & Osteoarthritis: OSTEOLOGIX (USA, 2010), GALAPAGOS (NDL, 2010), KAROS (USA, 2010), NORDIC BIOSCIENCE (DK, 2006/2010)
  • References

    Laboratoires Servier Wikipedia


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