Scott was born in Atlanta, Georgia. Her mother Gloria McFarlin was a teacher and her father Randolph Scott a pastor. Music was a constant in Scott's life as her father and two uncles sang in a group called the Scott Three in the 1970s. By age six, Scott had begun singing in church, weddings, and local talent shows. By age 11, she had recorded her first song with her father. She lives with her husband (Rocky Bivens), and son Jamon. Jamon now plays basketball at Troy U in Alabama.
Prior to joining Xscape, Scott had been performing with a group called Precise. While attending Tri-Cities performing arts high school in East Point, Georgia, Scott's sister Tamika met Kandi Burruss. The three began singing together and recruited a fourth member, Tamera Coggins, though her time with the group was short-lived. Soon Tameka "Tiny" Cottle was asked to audition for the girls, and Xscape was officially formed. After the group's major debut performance at BET's Teen Summit in 1992, the girls were introduced to record executive Ian Burke, who later became the group’s manager. Xscape soon caught the attention of Jermaine Dupri, who later signed the group to his So So Def Recordings.
The group released their debut album, Hummin' Comin' at 'Cha on October 12, 1993. The album peaked at number seventeen on the U.S. Billboard 200 and number three on the Top R&B Albums chart. It was a critical and commercial success, certified platinum within a year, and launched two hit singles. The two lead singles, "Just Kickin' It" and "Understanding", both entered the top 10 on the Billboard Hot 100 and peaked at number one on the Hot R&B/Hip-Hop Songs chart. The follow-up singles, "Love on My Mind" and "Tonight", did not achieve the same success. The group later appeared on The Mask soundtrack and the soundtrack for the 1995 film Panther, featuring the single "Freedom".
Xscape released their second studio album, Off the Hook, in 1995. Much of the album's production was by Jermaine Dupri and featured guest vocals from MC Lyte. Four singles were released. "Feel So Good" and "Who Can I Run To" peaked at #32 and #8 on the Billboard Hot 100 chart respectively. The latter release, "Can’t Hang/Do You Want To", was a joint single and reached the top ten of the Billboard R&B charts. "Off the Hook" was certified platinum in 1995. In 1996, the group was featured on MC Lyte's single "Keep On, Keepin' On", which appeared on the Sunset Park soundtrack. The single reached the top 10 on the Billboard Hot 100 chart. In 1997, as the group's popularity grew, they appeared on the soundtracks of the films Love Jones and Soul Food.
In 1997, the group found new management and released their third studio album, Traces of My Lipstick in 1998. The album entered the Billboard 200 at number 28, and featured top 10 hits "The Arms of the One Who Loves You" and "My Little Secret", which Scott co-wrote with Jermaine Dupri, earning the pair an ASCAP Rhythm and Soul Music Award. In early 1998, Xscape was featured on the Keith Sweat-produced single, "Am I Dreamin'", by R&B newcomer group Ol' Skool.
The dynamic of the group had changed by the third album, which led to Scott leaving the group in 1999 to pursue a solo career. Subsequently, the group went on hiatus. An attempt at a fourth album was made in 2004 but the project was scrapped due to a lack of promotion.
Emerging as a solo artist, Scott appeared solo on NFL Jamz in 1998 with a song entitled "Promises". She later released the single "Liar Liar", which appeared on The Best Man soundtrack in 1999.
By the early 2000s, Scott had ventured more into performing as a solo artist. She soon reconnected with ex-manager Michael Mauldin and signed a recording contract with Sony Urban. Scott's debut solo album with Sony was never released, due to label issues, forcing her to leave the label in 2001. Shortly after, Scott collaborated with rapper Trick Daddy on the song "Thug Holiday" in 2002. Without major label distribution, Scott eventually completed her debut album, Solo Flight 404, featuring the single "Still Ghetto".
In 2004, Scott, along with Tamika Scott, Tameka "Tiny" Cottle, and new member Kiesha Miles, attempted to revamp Xscape. They released the single "What’s Up" in 2005, but the reconciliation was short-lived and the group ultimately disbanded in 2005.
Around the same time, Scott made her first film appearance in the 2005 comedy, Fair Game.
LaTocha Scott released a new single entitled "Bad Timing" from her studio album, released in 2012.
She starred in the second season of the TV One show R&B Divas: Atlanta in 2013.Solo Flight 404 (2003)