Species Human Entrez 90678 | Human Mouse Ensembl ENSG00000148356 | |
Aliases LRSAM1, CMT2P, RIFLE, TAL, leucine rich repeat and sterile alpha motif containing 1 External IDs MGI: 2684789 HomoloGene: 44526 GeneCards: LRSAM1 | ||
E3 ubiquitin-protein ligase LRSAM1, previously known as Tsg101-associated ligase (Tal), is an enzyme that in humans is encoded by the LRSAM1 gene.
Contents
Clinical significance
Mutations in LRSAM1 have been reported in the peripheral neuropathy Charcot-Marie-Tooth type 2P (OMIM 614436), while disruption of the mouse Lrsam1 gene has been shown to sensitize peripheral axons to acrylamide-induced degeneration.
Interactions
LRSAM1 has been shown to interact with TSG101.
References
LRSAM1 Wikipedia(Text) CC BY-SA