Entrez 29124 | Ensembl ENSG00000105198 | |
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Aliases LGALS13, GAL13, PLAC8, PP13, galectin 13 External IDs HomoloGene: 49329 GeneCards: LGALS13 | ||
Galactoside-binding soluble lectin 13 or placental protein 13 (PP13) is a protein that in humans is encoded by the LGALS13 gene.
Contents
Structure and function
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family.
Clinical significance
PP13 levels that are low in the first trimester of pregnancy confers a higher risk for developing pre-eclampsia later in pregnancy.
References
LGALS13 Wikipedia(Text) CC BY-SA