Species Human Entrez 23641 | Human Mouse Ensembl ENSG00000182195 | |
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Aliases LDOC1, BCUR1, Mar7, Mart7, leucine zipper, down-regulated in cancer 1 External IDs MGI: 2685212 HomoloGene: 32153 GeneCards: LDOC1 | ||
Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.
Contents
Function
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.
Interactions
LDOC1 has been shown to interact with ABLIM1.
References
LDOC1 Wikipedia(Text) CC BY-SA