After studying business and international studies at the University of Pennsylvania, graduating in 1988, Bohner began her career in the mergers and acquisitions department at investment bank Lazard. After she left Lazard, she attended the Columbia University School of Journalism, where she received a Reader's Digest Literary Foundation Fellowship Award, graduating in 1992 with a Master of Science degree in journalism. Upon graduating from the Columbia Journalism School she joined Forbes magazine.
At Forbes, Bohner was promoted to writer after 13 months. Her work appeared in the Small Business, Healthcare, Careers, investigative, and other sections of the magazine. She was then asked to reinvent the column “The Informer,” rising to associate editor. During her time at Forbes, she was an on-air contributor to CNN and to E! Entertainment Network. She has also written for publications such as Harper’s Bazaar, Marie Claire, and George Magazine. She co-authored Donald Trump's 1997 book Trump: The Art of the Comeback. The book hit both the New York Times (#3), the Wall Street Journal (#1) and Businessweek (#2) Bestseller's Lists. That same year she became a correspondent for CNBC, launching “Business Center”, with Maria Bartiromo and Tyler Mathisen. She went on to write and broadcast “Kate Bohner’s Power File” on CNBC’s Power Lunch. In 1998, Jack Reilly, the former executive producer at CNBC joined her and other NBC veterans in founding a startup, Internet news service, JAGfn, providing online content similar to that found on CNBC.
In 2000, she was recruited as managing editor of digital financial media for E*Trade's start-up financial-news effort, a six-day per week webcast from New York City—the show also aired on Sundays on WNEW 102.7 FM. Bohner co-founded medical technology start-up Living Independently, Inc./QuietCare Systems (Care Innovations) in 2001, where she served as chief marketing officer and chief operating officer. In 2006, the company was sold to GE Healthcare and Intel.
Bohner launched “Kate’s Take” on her own YouTube channel KBTVonline in 2006. KBTVonline was a four-minute daily videoblog based and shot in South Florida. The show covered a wide range of information from top news stories to quirky pop culture, finance, politics, healthcare and style. On Christmas Day of 2007, KBTVonline's video hit #1 in 19 countries. Bohner left South Florida for Los Angeles in 2008 and in 2010, Bohner co-founded and became national director of Flybarre, a fitness program part of Flywheel Sports. In 2012, Bohner became chief marketing officer and director of communications at the World Trade Financial Group.
In 2013, Bohner joined DMS Offshore Investment Services Ltd., the world's largest fund governance firm, where she currently serves as chief communications, research & marketing officer and managing director
In July 2015, Bohner appeared on CNN to discuss her experience of working with presidential candidate Donald Trump.
Bohner was reported to be in a relationship with Google's executive chairman Eric Schmidt from 2006 to 2010. She was previously married to author Michael Lewis, known for his bestselling books Liar's Poker, The New New Thing, The Blind Side, and Moneyball. In November 2008, Bohner traveled to Thailand to live in a monastery and was ordained as a Buddhist nun.
Bohner was honored for her work in raising awareness about VVF in Nigeria while following Physicians for Peace through video and internet content, receiving the 2008 PFP President¹s Award for Special Achievement.