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Kang Yell Choi

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Kang-Yell Choi, Ph.D. is an academic.

Contents

He completed his doctorate in Biochemistry at the Purdue University in 1993. Then, Kang-Yell Choi performed research related to cell signaling at Harvard Medical School as a postdoctoral fellow. His research at Harvard investigated the function of Saccharomyces Ste5 involving pheromone response via MAP kinase pathway and was published as the 1st paper introducing the concept of "Scaffold protein" in the community.

In 1995, he returned to Korea as a professor of Yonsei University. Since then, he has been working on mammalian cell signaling. Dr. Choi identified a novel mechanism of Ras stability regulation via the Wnt/beta-catenin signaling. The degradation of Ras, especially K-Ras, is controlled by GSK3-mediated phosphorylation followed by ubiquitin-dependent proteasomal machinery via recruiting beta-TrCP E3 ligase. The stabilization of oncogenic K-Ras by APC loss and subsequent re-activation the Wnt/beta-catenin pathway via positive loop through ERK activated cancer stem cells and induced liver metastasis of colorectal cancer. This indicates the importance of inhibition of both Wnt/beta-catenin and Ras-ERK pathways in the treatment of colorectal cancer. He subsequently identified and characterized small molecules degrading both beta-catanin and Ras via targeting the Wnt/beta-catenin signaling, and those small molecules efficiently inhibit growth of colorectal and other cancers with activated Wnt/beta-catenin and EGFR-Ras pathways. He served as the Chief of the National Research Laboratory of the Molecular Complex Control in Yonsei University for recent 5 years. He is currently positioned as the Director of the Translational Research Center for Protein Function Control (TRCP) supported by Korean National Research Foundation and Ministry of Science, ICT and Future Panning of Korea.

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University Translational Research Center for Protein Function Control, College of Life Science and Biotechnology, Yonsei University.

Education

  • 1978-1985: BS, Department of Biotechnology, Yonsei University
  • 1988-1993: Ph.D., Department of Biological Sciences, Biochemistry, Purdue University, USA
  • 1993-1995: Post-doctor Harvard Medical School, Dept. of Biological Chemistry & Mol. Pharmacology, USA

    • Work summary

    Professional experience:

  • 1995-1999 : Assistant Professor Dept of Biochem. & Mol. Biol. Col. of Medicine, Yonsei University
  • 2000-2001 : Associate Professor Dept of Biochem. & Mol. Biol., Dept. Biotech, Yonsei University
  • 2001-2003 : Associate Professor Dept of Biotechnology, College of Life Sci. Biotech., Yonsei University
  • 2004-Current : Professor Dept of Biotechnology, College of Life Sci. Biotech., Yonsei University

    • Professional service:

  • 1993-1995 Post-doctor Harvard Medical School, Department of Biochemistry and Molecular Pharmacology
  • 2006-2007 Chairman Graduate Studies of the Functional Genomics Program, Yonsei Univ.
  • 2000-2009 Scientific Director Genepia Co.
  • 2006 Member Selection committee for Korea top 10 development, Ministry of Industrial Affair
  • 2008-2011 Review Board IRB for animal and human research, Yonsei University
  • 2008 Visiting Scholar University of California San Diego
  • 2009 Planning Review Board, Life Science (Korean Science Foundation)
  • 2004-2007 Acting Director Research Institute of Global Leadership
  • 2004 Member Board of Disease Control of Korean Government
  • 2004 Member National Patent Attorney Test and Selection Committee of Korea
  • 2005-2009 Chief National Research Laboratory (NRL)
  • 2004-current Advisory Board Cellular Dynamics Center, Research Center for Signaling Defect Bio-medical Research Center etc.
  • 2011-current Chief Do-Yak (2nd NRL)
  • 2008 Visiting Professor Department of Molecular Pharmacology, UCSD
  • 2008-2010 Chair, Department of Biotechnology, Yonsei University
  • 2009-current Director Translational Research Center for Protein Function Control, ERC
  • 2012 Board Recommending member of Ho-Am (Sam Sung’s establisher) Prize
  • 2013 Planning and Advisory Member, Enforcement pursue team of for evaluation of basic research, Ministry of Science, ICT and Future Planning, Korea
  • 2015 Board, Evaluation Committee for Company Establishment, Yonsei University
  • 2015 President, Korean Society for Cell Biology
  • 2016-current Chief, ERC center
  • 2016-current Underwood Distinguished Professor, Yonsei University

    • Publications

    Publications (cited by pubmed)

  • Cha PH, Cho YH, Lee SK, Lee JH, Jeong W-J, Moon B-S, Yun JH, Yang JS, Choi SH, Yoon JY, Kim HY, Kim, MY, Kaduwal S, Lee W, Min DS, Kim Hg, Han GH, and Choi KY. Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation. Nature Chemical Biology. 12, 593-600 (2016).
  • Kim, HY, Choi, S, Yoon JH, Lim HJ, Lee H, Choi J, Neo JN, Lee W, No, KT, and Choi, KY. Small molecule inhibitors of Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Molecular Medicine 8, 375-387 (2016).
  • Kim, MY., Kim HY, Hong J., Kim D, Lee H, Cheong, E., Lee, Yangsin, Roth J., Kim, DG, Min DS., and Choi, KY. CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. Glia. 64(3), 350-362. (2016).
  • Park JC, Jeong WJ, Kim MY, Min DS, and Choi, KY. Retinoic Acid-Mediated HRas Stabilization Induces Neuronal Differentiation of Neural Stem Cells during Brain Development. Journal of Cell Science. 129, 2997-3007. (2016).
  • Cho YH, Cha P, Kaduwal S, Park JC, Lee SK, Yoon JS, Shin W., Kim H, Ro EJ, Koo KH, Park KS, Han GH, and Choi, KY. KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer. Oncotarget. Nov 7. doi: 10.18632/oncotarget.13172. [Epub ahead of print] (2016)
  • Lee, YM, Kaduwal S, Lee KH, Park JC, Jeong WJ, and Choi KY. Sur8 mediates tumorigenesis and metastasis in colorectal cancer. Experimental & Molecular Medicine. 48, e249. (2016).
  • Seo, SH., Lee, SH, Cha, PH, Kim, MY, Min, DS, Choi, KY. Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing. Phytotherapy Research. 30, 848-854 (2016).
  • Cha, P.H., and Choi, K.Y. Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer. BMB Report. 49, 455-456. (2016).
  • Kang DW, Hwang WC, Choi KY, and Min DS. Rebamipide attenuates Helicobacter pylori CagA-induced self-renewal capacity via modulation of β-catenin signaling axis in gastric cancer-initiating cells.. Biochem. Pharmacology. 113:36-44. (2016)
  • Kang, DW., Lee, SW, Hwang, WC, Lee, BH, Choi, YS, Suh, YA, Choi, KY., Min, DS. Phospholipase D1 acts through Akt/TopB1 and RB1 to regulate the E2F1-dependent apoptotic program in cancer cells. Cancer Research. [Epub ahead of print] (2016).
  • Lee SH, Kim MY, Kim HY, Lee YM, Kim HS, Nam KA, Roh MR, Min DS, Chung KY, and Choi KY. The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. Journal of Experimental Medicine. 212(7):1061-80. (2015)
  • Koo KW, Jeong WJ, Cho YH, Park, JC, Min DS, and Choi KY. K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis. Oncotarget. 6(25):21328-40. (2015).
  • Kim HY, Yoon JY, Yoon JH, Cho KW, Lee, SH, Rhee, YM, Jung, HS, Lim HJ, Choi, JW, Heo JN, Lee WT, No KT, Min DS, and Choi KY. CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Cell Death and Differentiation. 22(6):912-20. (2015)
  • Park MH, Choi KY, Min DS. The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5. Experimental & Molecular Medicine. 47:e200.. (2015)
  • Park MH, Bae SS, Choi KY, and Min DS. Phospholipase D2 promotes degradation of hypoxia-inducible factor-1a, independent of lipase activity. Experimental & Molec lar Medicine. 47:e196. (2015)
  • Kaduwal S, Jeong WJ, Park JC, Lee KH, Lee YM, Jeon SH, Lim YB, Min DS, and Choi KY. Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling. Oncotarget.. 6(32), 33091-105. (2015)
  • Kang DW, Choi CY, Cho YH, Tian H, Paolo GD, Choi KY, and Min DS. Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells. Journal of Experimental Medicine. 212(8):1219-37. (2015)
  • Kim, B, Lee, S-H., Choi, KY, Kim, H-S. N-nicotinoyl tyramine, a novel niacinamide derivative, inhibits mela- nogenesis by suppressing MITF gene expression. European Journal of Pharmacology 764. 1–8 (2015)
  • Hwang JH, Cha PH, Han GH, Min DS, Choi KY. Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation. Experimental & Molecular Medicine. 47:e152. (2015)
  • Kim KH, Kim DY, Park JY, Jung HJ, Cho YH, Kim HK,, Han J, Choi KY, and Kwon HJ. NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1. Journal of Molecular Medicine. 93(5):499-509. (2015) (IF=4.739)
  • Moon BS, Jeong WJ, Park J, Kim TI, Min DS, and Cho KY. Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling. Journal of the National Cancer Institute. 106(2):djt 373. (2014)
  • Moon BS, Cho YH, Jeong WJ, and Choi KY. Response. Journal of the National Cancer Institute. 106 (8): dju 197. (2014)
  • Kim HY, Yang DH, Shin SW, Kim MY, Yoon JH, Kim S, Park HC, Kang DW, Min DS, Hur MW, and Choi KY. CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation. FASEB Journal. 28(2), 615-26. (2014)
  • Zahoor M, Cha PH, and Choi KY. Indirubin-3'-Oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restore bone loss in high-fat diet-induced obese male mice. Bone. 65:60-68. (2014)
  • Cha PH, Shin WJ, Zahoor M, Kim HY, Min DS, and Choi KY. Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. PLoS One. e85546. (2014)
  • Jeong WJ, Cha PH, and Choi KY. Strategies to overcome resistance to EGFR monoclonal antibody therapy in metastatic colorectal cancers. World Journal of Gastroenterology. 20(29): 9862-9871 (2014) (IF=2.433) (Selected as a featured article on MDLinx on 9 August, (2014))
  • Park MH, Choi KY, Jung Y, and Min DS. Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability. Oncotarget. 5(23):11857-72. (2014)
  • Hwang WC, Kim MK, Song JH, Choi KY, and Min DS. Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells. Experimental and Molecular and Medicine. 46:e124. (2014) (IF=2.462)
  • Zahoor M, Cha PH, Min DS, and Choi KY. Indirubin-3’-oxime Reverses Bone Loss in Ovariectomized and Hindlimb-Unloaded Mice via Activation of the Wnt/β-Catenin Signaling. Journal of Bone and Mineral Research. 29:1196-1205. (2014)
  • Choi OM, Cho YH, Choi S, Lee SH, Seo SH, Kim HY, Han GH, Park TS, Min DS, and Choi KY. The small molecule indirubin-3´-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity. International Journal of Obesity. 38:1044-52. (2014)
  • Kang DW, Choi KY, and Min DS. Functional Regulation of Phospholipase D Expression in Cancer and Inflammation. Journal of Biological Chemistry. 289: 22575-82. (2014)
  • Jang YH, Choi KY, and Min DS. Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy. Cell Death and Differentiation. 21:533-46. (2014)
  • Park MH, Kang DW, Jung Y, Choi KY, and Min DS. Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFκB transactivation. Biochemical and Biophysical Research Communications. 442:1-7. (2013)
  • Kim B, Choi SJ, Han SH, Choi KY, and Lim YB. Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition. Chemical Communications. 49:7617-9. (2013)
  • Son JC, Kang DW, Yang KM, Choi KY, Son TG, and Min DS. Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells. Experimental and Molecular Medicine. 45:e38. (2013)
  • Ro EJ, Cha PH, Kim HY, Cho YH, Park JW, Han JS, and Choi KY, House dust mite allergen Derf2 induces interleukin-13 expression by activating the PI3K/Akt pathway, Immunologic Research. 56:181–8. (2013) (highlighted by MDLinx)
  • Kim MY, Moon BS, and Choi KY. Isolation and maintenance of cortical neural progenitor cells in vitro. Methods in Molecular Biology. 1018:3-10. (2013) (IF=1.29) (“BookChapter”-Springer)
  • Kang DW, Park MK, Oh, HJ, Lee DG, Park SH, Choi KY, Cho ML, and Min DS. Phospholipase D1 has a pivotal role in IL-1β-driven chronic autoimmune arthritis through regulation of NFκB, HIF-1α and FoxO3a. Molecular and Cellular Biology. 33: 2760-72. (2013)
  • Song D, Yang JS, Kim SJ, Kim BK, Park SK, Won M, Lee K, Kim HM, Choi KY, Lee K, and Han G. Design synthesis and bilological evalulation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents. Bioorganic and Medicinal Chemistry. 21:788-94 (2013)
  • Jeong WJ, Yoon JY, Park JC, Lee SH, Lee SH, Kaduwal S, Kim HG, Yoon JB, and Choi KY. Ras Stabilization via Aberrant Activation of Wnt/b-catenin Signaling Promotes Intestinal Tumorigenesis. Science Signaling. 5(219):ra30. (2012)
  • Lee SH, Zhahoor M., Hwang JK. Min DS, and Choi KY. Valproic acid induces cutaneous wound healing invivo and enhances keratinocyte motility. PLoS One. 7: e48791. (2012)
  • Lee SH, Yoon JY, Shin SH, Zahoor M, Kim HJ, Park PJ, Park WS, Min DS, Kim HY, and Choi KY. Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. PLoS One. 7:e34152 (2012)
  • Kim BR, Kim JE, Kim H, Lee JD, Choi KY, and Lee SH. Co-treatment with retinyl retinoate and PPARα agonist reduces retinoid dermatitis. International Journal of Dermatology. 6, 733-41 (2012) (IF=1.227) (Co-corresponding author)
  • Park PJ, Moon BS, Lee SH, Kim SN, Kim AR, Kim HJ, Park WS, Choi KY, Cho EG, and Lee TR. Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin. Life Sciences. 91(19-20):935-43 (2012)
  • Jeon BN, Kim MK, Choi WI, Koh DI, Hong SY, Kim KS, Kim MJ, Yun CO, Yoon JY, Choi KY, Lee KR, Kenneth P. Nephew, Hur NW. KR-POK interacts with p53 and represses CDKN1A transcription activation by p53. Cancer Research. 72(5):1137-48. (2012)
  • Kang DW, Hwang WC, Park MH, Ko GH, Ha WS, Kim KS, Lee YC, Choi KY, and Min DS. Rebamipide abolishes Helicobacter pylori CagA-induced phospholipase D1 expression via inhibition of NFkB and suppresses invasion of gastric cancer cells. Oncogene. 32(30):3531-42. (2012)
  • Yoon JY, Koo KH, and Choi KY. MEK1/2 Inhibitors, AS703026 and AZD6244, may be potential therapies for K-ras Mutated Colorectal Cancer that Is resistant to EGFR Monoclonal Antibody Therapy. Cancer Research. 71(2):445-53. (2011)
  • Moon BS, Kim HY, Kim MY, Yang DH, Lee JM, Cho KW, Jung HS, and Choi KY. Sur8/Shoc2 Involves Both Inhibition of Differentiation and Maintenance of Self-renewal of Neural Progenitor Cells via Modulation of ERK Signaling. Stem Cells. 29:320-31 (2011)
  • Kim BR, Kim JE, Lee SM, Lee SH, Lee JW, Kim MK, Lee KJ, Kim H, Lee JD, and Choi KY. N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high anti-oxidant activity and inhibits skin pigmentation. Experimental Dermatology. 20(11):950-2 (2011)
  • Lee SH, Kim BR, Oh MJ, Yoon JY, Kim HY, Lee KJ, Lee JD, and Choi KY. Persicaria hydropiper (L.) Spach and its Flavonoid Components, Isoquercitrin and Isorhamnetin, Activate the Wnt/β-catenin Pathway and Inhibit Adipocyte Differentiation of 3T3-L1 Cells. Phytotherapy Research. 25(11):1629-35 (2011)
  • Yao TW, Kim WS, Yu DM, Sharbeen G, McCaughan GW, Choi KY, Xia P, and Gorrell MD. A novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling. Molecular Cancer Research. 9(7):948-59. (2011)
  • Shin MK, Jang YH, Yoo HJ, Kang DW, Park MH, Kim MK, Song JH, Kim SD, Min GS, You HK, Choi KY, Bae YS, and Min DS. N-Formyl-Methionyl-Leucyl-Phenylalanine (fMLP) Promeucs Osucoblast Differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in Human Mesenchymal Stem Cells from Bone Marrow. Journal of Biological Chemistry. 286(19):17133-43. (2011)
  • Kang DW, Choi KY, and Min DS. Phospholipase D Meets Wnt Signaling: A New Target for Cancer Therapy. Cancer Research. 71(2):293-7. (2011)
  • Kim MY, Kaduwal S, Yang DH, and Choi KY. BMP4 stimulates attachment of neurospheres and astrogenesis of neural stem cells in neurospheres via PI3 kinase-mediated upregulation of N-cadherin. Neuroscience. 170(1):8-15. (2010)
  • Kang DW, Lee SH, Yoon JW, Park WS, Choi KY, and Min DS. Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/ß-catenin/TCF signaling axis. Cancer Research. 70(10):4233-42. (2010)
  • Kim JE, Kim BR, Kim H, Kim HJ, Lee JD, Kim HJ, Choi KY, and Lee SH. Retinyl retinoate induces hyaluronan production and less irritation than other retinoids. Journal of Dermatology. 37(5):448-54. (2010)
  • Yang DH, Yoon JY, Lee SH, Bryja V, Andersson ER, Arenas E, Kwon YG, and Choi KY. Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/β-Catenin and Protein Kinase Ca. Circulation Research. 104(3):372-9. (2009)
  • Park CY, Choi SH, Kang SM, Kang JI, Ahn BY, Kim HG, Jung GH, Choi KY, and Hwang SB. Nonstructural 5A protein activates β-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis. Journal of Hepatology. 51(5):853-64. (2009)
  • Kim SE, Yoon JY, Jeong WJ, Jeon SH, Park Y, Yoon JB, Park YN, Kim HG, and Choi KY. H-Ras is degraded by Wnt/β-catenin signaling via β-TrCP-mediated polyubiquitination. Journal of Cell Science. 122(Pt 6):842-8. (2009) (Cover story paper)
  • Lee MY, Jeong WJ, Oh JW, and Choi KY. NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway. Cancer Letters. 275(2):221-6. (2009)
  • Choi WI, Jeon BN, Yun CO, Kim PH, Kim SE, Choi KY, Kim SH, and Hur MW. Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by P53 and Sp1. Journal of Biological Chemistry. 284(19):12633-44. (2009)
  • Moon BS, Yoon JY, Kim MY, Lee SH, Choi SJ, and Choi KY. BMP4 stimulates neuronal differentiation of neuronal stem cells through ERK pathway. Experimental and Molecular Medicine. 41(2):116-25. (2009)
  • Lee HJ, Koh JM, Hwang JY, Choi KY, Lee SH, Park EK, Hong JM, Han BG, Kim GS, Kim SY and Lee JY. Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women. Calcified Tissue International. 84(6):439-45. (2009)
  • Kang SM, Kim SJ, Kim JH, Lee WS, Kim GW, Lee KH, Choi KY, and Oh JW. Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis. Cancer Letters. 279(2):230-7. (2009)
  • Lee JW, Kim WH, Lim JH, Song EH, Song JH, Choi KY, and Jung MH. Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells. Cellular Signalling. 21(1):69-78. (2009)
  • Jung GA, Yoon JY, Moon BS, Yang DH, Kim HY, Lee SH, Bryja V, Arenas E, and Choi KY. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway. BMC cell biology. 9:66. (2008)
  • Jeon SH, Yoon JY, Park YN, Jeong WJ, Kim S, Jho EH, Surh YJ, and Choi KY. Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin. Journal of Biological Chemistry. 282(19):14482-92. (2007) (Selected as SCIENCE STKE Noteworthy contribution to Scientific Literature)
  • Kim SE and Choi KY. EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation. Cellular Signaling. 19(7):1554-64. (2007) (Selected as highly downloaded article)
  • Lee WJ, Kim DU, Lee MY and Choi KY. Identification of proteins interacting with the catalytic subunit of PP2A by proteomics. Proteomics. 7(2):206-14. (2007) (IF=3.973) (Introduced as a Podcast Article in Homepage)
  • Jeon SH, Jeong WJ, Cho JY, Lee KH and Choi KY. Axin is involved in the inhibition of cell proliferation by EGF. Experimental and Molecular Medicine. 39(4):491-8. (2007)
  • Kim SE, Lee WJ and Choi KY. The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation. Cellular Signaling. 19(3):511-8. (2007)
  • Lee JH, Lee JS, Kim SE, Moon BS, Kim YC, Lee SK, Lee SK and Choi KY. Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the ERK pathway. Molecular Cancer Therapeutics. 5(12):3222-31. (2006)
  • Park KS, Jeon SH, Kim SE, Bahk YY, Holmen SL, Williams BO, Chung KC, Surh YJ, and Choi KY. APC inhibits ERK pathway activation and cellular proliferation induced by Ras. Journal of Cell Science. 119(Pt 5):819-27. (2006)
  • Ju YJ, Park JE, Juhn KM, Jeong J, Yun M, Park MJ, Choi KY, Choi MH, Wong KK, and Lee KH. Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53. International Journal of Oncology. 29(4):753-63. (2006)
  • Han BG, Lee HJ, Kim KJ, Jeon JP, Lee HJ, Jeon JP, Kim JW, Kim H.T. Cha HS, Kim CH, Choi KY, Park C, Oh BS, Kim KC, and Lee JY. Chromosomal Information of 1,144 Korean BAC Clones. Genomics & Informatics. 4(4):141-6. (2006)
  • Kund JK, Choi KY and Surh YJ. Beta-catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances. Biochimica et biophysica acta (BBA) - Reviews on Cancer. 1765(1):14-24. (2006)
  • Jeong JH, Ju YJ, Kim BY, Park MJ, Kim TH, Park CI, Choi KY, Cho MH, Kim SH, and Lee KH. Temporal cDNA microarray analysis of gene expression in human hepatocellular carcinoma upon radiation exposure. Oncology Reports. 15(1):33-48. (2006)
  • Lee JA, Suh DC, Kang JE, Kim MH, Park H, Lee MN, Kim JM, Jeon BN, Roh HE, Yu MY, Choi KY, Kim KY, and Hur MW. The transcriptional activity of Sp1 is regulated by molecular interaction between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK. The Journal of Biological Chemistry. 280(30):28061-71. (2005)
  • Yun MS, Kim SE, Jeon SH, Lee JS and Choi KY. Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation. Journal of Cell Science. 118(Pt 2):313-22. (2005) (Cover story In this issue)
  • Kim YC, Jung JW, Park HY, Kim HY, Choi KY and Lee WT. Solution Structure of a GSK3β Binding Motif, AXIN. Journal of the Korean Magnetic Resonance Society. 9:38 -47. (2005)
  • Kim SE, Cho JY, Kim KS, Lee SJ, Lee KH and Choi KY. Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells. Cellular Signaling. 16(11):1309-17. (2004)
  • Kim M, Cha GH, Kim S, Lee JH, Park J, Koh H, Choi KY, Chung J. MKP-3 acts essential roles as a negative regulator of the Ras/MAPK pathway during Drosophila development. Molecular and Cellular Biology. 24(2):573-83. (2004)
  • Kim BY, Lee JG, Park SH, Ahn JY, Chung JH, Han CS, Jeong SH, Choi KY, and Lee KH. Feature gene of hepatitis B virus-positive hepatocellular carcinoma, established by its molecular discrimination approach using prediction analysis of microarray. Biochimica et Biophysica Acta. 1739(1):50-61. (2004)
  • Park KS, Jeon SH, OH JW and Choi KY. Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells. Experimental and Molecular Medicine. 36(6):557-62. (2004)
  • Han RN, Cho IH, Chung SO, Lee JK, Han JK and Choi KY. Identification of potential Corynebacterium ammoniagenes purine gene regulators using the pur-lacZ reporter in Escherica coli. Journal of Microbiology and Biotechnology. 36(6):557-62.(2004)
  • Yeun EH., Noh JY, Kim JM, Lee MY, Yoon S, Park SK, Choi KY and Kim KS. Control of transcriptional regulation in eukaryotes by a novel transcription factor derived from E. coli purine repressor. Biochemical and Biophysical Research Communications. 319(2):334-41. (2004)
  • Lee KH, Jung YJ, Hong CI, Cho MH, Kim SH, Choi KY and Kim CM. Activation of protein kinase C by 1-beta-D-arabinofuranosylcytosine conjugates of phospholipid. International Journal of Oncology. 24, 193-199. (2004)
  • Kim SE, Kim SH and Choi KY. Enzymatic activation and stabilization of Drosophila MKP-3 by Drosophila ERK. Annals of the New York Academy of Sciences. 1010:51-61. (2004)
  • Park KS, Lee NG, Lee JT and Choi KY. The ERK pathway involves positive and negative regulations of HT29 colorectal cancer cell growth by extracellular zinc. American journal of physiology. Gastrointestinal and liver physiology. 285(6):G1181-8. (2003)
  • Park KS, Ahn Y, Kim JA, Yun MS, Seong BL, and Choi KY. Extracellular zinc stimulates ERK-dependent activation of p21Cip/WAF1 and inhibits proliferation of colorectal cancer cells. British Journal of Pharmacology. 137(5):597-607. (2002)
  • Kwon HB, Kim SH, Kim SE, Jang IH, Ahn YH, Lee WJ, and Choi KY. Drosophila extracellular signal regulated kinase involves in the insulin mediated proliferation of Schneider cells. The Journal of Biological Chemistry. 277(17):14853-8. (2002)
  • Kim HI, Cha JY, Kim SY, Kim JW, Roh KJ, Seong JK, Lee NT, Choi KY, Kim KS and Ahn YH. PPARγ upregulates the glucokinase gene expression in β cells. Diabetes. 51(3):676-85. (2002)
  • Kim JA, Park KS, Kim HI, Oh SY, Ahn YH, Oh JW, and Choi KY. Troglitazone Activates p21Cip/WAF1 through the ERK Pathway in HCT15 Human Colorectal Cancer Cells. Cancer Letters. 179(2):185-95. (2002)
  • Kim SH, Kwon HB, Kim YS, Ryu JH, Kim KS, Ahn YH, Lee WJ, and Choi KY. Isolation and characterization of a Drosophila homologue of MKP-3 which has a high substrate specificity toward ERK. The Biochemical Journal. 361(Pt 1):143-51. (2002)
  • Oh SY, Park KS, Kim JA and Choi KY. Differential modulation of zinc-stimulated p21Cip/WAF1 and cyclin D1 induction by inhibition of PI3 kinase in HT29 colorectal cancer cells. Experimental and Molecular Medicine. 34(1):27-31. (2002)
  • Choi KY. Regulation of the MAP kinase signaling pathway. Experimental and Molecular Medicine. Supplement. 34:17-33. (2002)
  • Kim TI, Jin SH, Kang EH, Shin SK, Choi KY, and Kim W. The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma indomethacin-induced apoptosis of colon cancer cells. Annals of the New York Academy of Sciences. 973:241-5. (2002)
  • Kim TI, Jin SH, Kim WH, Kang EH, Choi KY, Kim HJ, Shin SK and Kang JK. Prolonged activation of mitogen-activated protein kinases during NSAIDs-induced apoptosis in HT-29 colon cancer cells. International Journal of Colorectal Disease. 16(3):167-73. (2001)
  • Kim TI, Jin SH, Kang EH, Shin SK, Choi KY, and Kim W. The role of mitogen-activated protein kinases and their relationship with NF-kappaB and PPARgamma indomethacin-induced apoptosis of colon cancer cells. Annals of the New York Academy of Sciences. 973:241-5. (2001)
  • Lee WJ, Kim SH, Kim YS, Han SJ, Park KS, Ryu JH, Hur MW, and Choi KY. Inhibition of MAPK by Drosophila MAPK phosphatase. Biochemical Journal. 349 Pt 3:821-8. (2000)
  • Choi YJ, Kim SK, Kim SH, Lee KS, and Choi KY. Saccharomyces cerevisiae Ste5 is important for induction and substrate specificity of Fus3 MAP kinase in the pheromone signaling pathway. Molecules and cells. 10(3):301-8. (2000) (IF=2.242)
  • Choi YJ, Kim SH, Park KS, and Choi KY. Differential transmission of G1 cell cycle arrest and mating signals by Saccharomyces cerevisiae Ste5 mutants in the pheromone pathway. Biochemistry and Cell Biology. 77(5):459-68. (1999)
  • Park KS, Kim NG, Kim JJ, Kim H, Ahn Y. and Choi KY. Differential regulation of MAP kinase cascade in human colorectal tumorigenesis. British Journal of Cancer. 81. 1116-1121. (1999)
  • Choi KY, Kranz JA, Mahanty, S. K, Park, KS, and Elion EA. Characterization of Fus3 localization: Active Fus3 localizes in complexes of varying size and specific activity. Molecular Biology of the Cell. 10(5):1553-68. (1999)
  • Han SJ, Choi KY, Brey PT, and Lee WJ. Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase. The Journal of Biological Chemistry. 273(1):369-74. (1998)
  • Piao Z, Park C, Lee JS, Yang CH, Choi KY, and Kim H. Homozygous deletions of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma. Cancer Letters. 122(1-2):201-7. (1998)
  • Kim SH, Lee SK, and Choi KY. Saccharomyces cerevisiae STE11 may contribute to the stabilities of a scaffold protein, STE5, in the pheromone signaling pathway. Molecules and Cells. 8(2):130-7. (1998)
  • Choi KY. Ras signaling pathway and Cancer therapy. Focus on Genetic Science. 4: 1-16. (1997)
  • Glasfeld A, Choi KY, Zalkin H, and Brennan RG. A positively charged residue bound in the minor groove does not alter the bending of a DNA duplex. Journal of the American Chemical Society. 118:13073-74. (1996)
  • Lyons DM, Mahanty SK, Choi KY, Manandhar M, and Elion EA. The SH3-Domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae. Molecular and Cellular Biology. 16(8):4095-106. (1996)
  • Schumacher MA, Choi KY, Lu F, Zalkin H, and Brennan RG. Mechanism of corepressor-mediated specific DNA binding by the purine repressor. Cell. 83(1):147-55. (1995)
  • Choi KY and Choi YJ. Identification of an active form of Saccharomyces cerevisiae MAP kinase Fus3. Focus on Genetic Sciences. 3:63-68.
  • Choi KY, Satterberg B, Lyons DM, and Elion EA. Ste5 thether multiple protein kinase in the MAP kinase cascade required for mating in Saccharomyces cerevisiae. Cell. 78(3):499-512. (1994)
  • Choi KY, Lu F, and Zalkin H. Mutagenesis of amino acid residues required for binding of corepressors to the purine repressor. The Journal of Biological Chemistry. 9(39):24066-72. (1994)
  • Choi KY and Zalkin H. Role of the purine repressor hinge sequences in repressor function. Journal of Bacteriology. 176:1767-72. (1994)
  • Schumacher MA, Choi KY, Zalkin H, and Brennan RG. Crystal structure of LacI member RurR, bound to DNA: Minor groove binding by α helices. Science. 266(5186):763-70. (1994)
  • Schumacher MA, Choi KY, Zalkin H, and Brennan RG. Crystallization and preliminary X-ray analysis of an Escherichia coli purine repressor-hypoxanthine-DNA complex. Journal of Molecular Biolology. 242(3):302-5. (1994)
  • He B, Choi KY, and Zalkin H. Regulation of Escherichia coli glnB, prsA, and speA by purine repressor. Journal of Bacteriology. 175(11):3598-606. (1993)
  • Choi KY. Escherichia coli purine repressor; Regulation and structure function analysis. Ph.D. thesis. Purdue University (1993)
  • Choi KY and Zalkin H. Structural characterization and corepressor binding of Escherichia coli purine repressor. Journal of Bacteriology. 174(19):6207-14. (1992)
  • Schumacher MA, Choi KY, Zalkin H, and Brennan RG. Crystallization and preliminary X-ray studies on the corepressor binding domain of the Escherichia coli purine repressor. Journal of Molecular Biology. 225(4):1131-3. (1992)
  • Choi KY and Zalkin H. Regulation of Escherichia coli pyrC by the purine regulaon repressor protein. Journal of Bacteriology. 172(6):3201-7. (1990)
  • He B, Shiau A, Choi KY, Zalkin H, Smith JM. Genes of the Escherichia coli pur regulon are negatively controlled by a repressor-operator interaction. Journal of Bacteriology. 172(8):4555-62. (1990)

    • Category

  • Molecular Complex 기능제어 연구실
  • Yonsei university, Biotechnology
  • 단백질기능제어이행연구센터

    • References

    Kang-Yell Choi Wikipedia
    (Text) CC BY-SA