Samiksha Jaiswal (Editor)

Dishevelled

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Symbol
  
Dishevelled

InterPro
  
IPR003351

Pfam
  
structures

Pfam
  
PF02377

PROSITE
  
PDOC50841

PDB
  
RCSB PDB; PDBe; PDBj

Dishevelled

Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors. It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.

Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.

Members

There are three human genes that encode for the dishevelled proteins:

  • DVL1
  • DVL2
  • DVL3
  • References

    Dishevelled Wikipedia


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