Entrez 51621 | Ensembl n/a | |
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Aliases KLF13, BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13 External IDs MGI: 1354948 HomoloGene: 32288 GeneCards: KLF13 | ||
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.
Contents
Function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.
KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1. It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.
Interactions
KLF13 has been shown to interact with CREB-binding protein, Heat shock protein 47 and PCAF.