Kalpana Kalpana (Editor)

Heat shock protein 47

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Species
  
Entrez
  
871

Human
  
Ensembl
  
ENSG00000149257

Heat shock protein 47

Aliases
  
SERPINH1, AsTP3, CBP1, CBP2, HSP47, OI10, PIG14, PPROM, RA-A47, SERPINH2, gp46, serpin family H member 1

External IDs
  
OMIM: 600943 MGI: 88283 HomoloGene: 20331 GeneCards: SERPINH1

Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen.

Contents

Function

This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.

Interactions

Heat shock protein 47 has been shown to interact with collagens I, II, III, IV and V.

References

Heat shock protein 47 Wikipedia


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