Tripti Joshi (Editor)

Joseph Sambrook

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Name  Joseph Sambrook
Residence  Melbourne, Australia
Fields  Molecular biology

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Born  1 March 1939 (age 76) Liverpool, England (1939-03-01)
Institutions  MRC Laboratory of Molecular Biology, Salk Institute for Biological Studies, Cold Spring Harbor Laboratory, University of Texas Southwestern Medical Center, Peter MacCallum Cancer Centre
Alma mater  Australian National University
Known for  Laboratory manual Molecular Cloning, work on oncoviruses
Notable awards  Victorian Government Leadership and Innovation Award, Elected Fellow of the Australian Academy of Sciences and the Royal Society
Books  Molecular Cloning: A Laboratory Manual, The Condensed Protocols from Molecular Cloning : a Laboratory Manual
Education  University of Liverpool, Australian National University

Joseph Frank Sambrook (born 1 March 1939 in Liverpool, England) is a British molecular biologist known for his studies of DNA oncoviruses and the molecular biology of normal and cancerous cells. He resides in Melbourne, Australia with his wife and daughter.


Education and early career

Sambrook was educated at the University of Liverpool (BSc (hons) 1962) and obtained his PhD at the Australian National University in 1966. He did postdoctoral research at the MRC Laboratory of Molecular Biology (1966–67) and the Salk Institute for Biological Studies (1967–69). In 1969 he was hired by James D. Watson to work at the Cold Spring Harbor Laboratory in New York. Watson has been reported to say this was the best hiring decision he ever made. Joe was responsible for creating a combative creative environment at CSHL that fomented discovery. Subsequently he worked at the University of Texas Southwestern Medical Center (Dallas).


Sambrook is best known for his studies on DNA tumor viruses and the molecular biology of normal and neoplastic cells. His Tumour Virus Group at Cold Spring Harbor identified and mapped all of the major genes of adenoviruses and SV40, determined their transcriptional control in infected and transformed cells, and elucidated the mechanism of integration of these viruses into the genome of the host cell. He has also made important contributions to the understanding of intracellular traffic and protein folding and is an influential leader in the field of the molecular genetics of human cancer.

Sambrook is a former Director of Research at the Peter MacCallum Cancer Centre in Melbourne. He was elected a Fellow of the Australian Academy of Science in 2000. and is a Fellow of the Royal Society. He was the founder and director of the Kathleen Cunningham Consortium for research into familial breast cancer, KConFab, that was established in 1995.

Sambrook has published four editions of the best-selling, highly influential laboratory manual Molecular Cloning, the third in 2001 with David Russell and the fourth in 2012 with Michael R. Green. He is also co-editor of Inspiring Science: Jim Watson and the Age of DNA and Life Illuminated: Selected Papers from Cold Spring Harbor Volume 2, 1972–1994. All three books were published by Cold Spring Harbor Laboratory Press.

In 2009 he was awarded the "Victorian Government Leadership and Innovation Award".


Joseph Sambrook Wikipedia