Bramnick was born and raised in Plainfield, New Jersey as the son of Plainfield business owners (Lazaar's Stationers). He graduated from Plainfield High School, received a B.A. in Political Science from the Maxwell School of Citizenship and Public Affairs at Syracuse University and was awarded a J.D. from the Hofstra University School of Law.
Before becoming an Assemblyman, Bramnick served two terms as a City Councilman in Plainfield, New Jersey from 1984-1991. He is the Republican Municipal Chairman in Westfield, where he resides with his family. Bramnick is a former professor at both Rutgers University and Rider University. Following his graduation from law school, he served as an assistant corporation counsel in New York City. He is an attorney with a private practice in Scotch Plains, New Jersey with the firm of Bramnick, Rodriguez, Grabas, Arnold & Mangan.
Following the appointment of Tom Kean, Jr. to the State Senate, a vacancy opened up in the 21st District's Assembly delegation. Bramnick won the most ballots of a vote by members of the Essex, Morris, Somerset, and Union county Republican committee persons of the district beating former Assemblyman James J. Barry, Jr., Millburn mayor Thomas McDermott, and Warren Township Planning Board chairman Dan Gallic.
In December 2005 he was appointed Assistant Minority Whip of the Assembly for the 2006-2008 term. In June 2007, Bramnick was selected as the Minority Whip, succeeding Francis J. Blee. In November 2009, he was elected as the Republican Conference Leader, the second-highest leadership position in the Republican caucus. In the Assembly, he has served as a member of the Legislative Services Commission.
After the death of Assembly Republican Leader Alex DeCroce in January 2012, the Assembly Republican caucus chose Bramnick as its new leader.
Bramnick has been honored with the 2013 Governor Meyner Award from the Bar Association and the 2011 Legislator of the Year award from the Chamber of Commerce. He was named 2013 Legislator of the Year by the New Jersey Conference of Mayors and was honored at Rider University for his dedication to New Jersey politics and public service.
On January 3, 2017, Bramnick announced that he would not run for New Jersey governor in 2017, as he was seen as a potential frontrunner for the Republican gubernatorial nomination. Bramnick is seen as a potential 2018 Senate candidate against Sen. Robert Menendez.
Each of the 40districts in the New Jersey Legislature has one representative in the New Jersey Senate and two members in the New Jersey General Assembly. The other representatives from the 21st District for the 2016–2017 Legislative Session are:Senator Thomas Kean, Jr.
Assemblywoman Nancy Munoz
Bramnick holds the honorary title of "Funniest Lawyer in New Jersey" after winning contests sponsored by the bar association at Rascals Comedy Club. He often volunteers his services as a comedic auctioneer on behalf of non-profit organizations including Hurricane Sandy victims.
Bramnick resides in Westfield, New Jersey with his wife Patricia (married in 1981), and has two grown children and a granddaughter. He is Jewish.