John Loike (born 1950 in Stockholm, Sweden) is an American research biologist and bioethicist in Columbia University.
Loike has a Ph.D from the Albert Einstein College of Medicine of Yeshiva University. His research focuses on the role of inflammation in cancer and neurodegenerative diseases. He has published many articles in leading scientific journals including Science, Nature, Journal of Experimental Medicine, Journal of Cell Biology, New England Journal of Medicine, Lancet, PNAS, PlosOne, Journal of Biological Chemistry and The Scientist. In addition he has authored or co-authored several books.
He is the Director for Special Programs for the Center for Bioethics in Columbia University and is a faculty member of the Department of Physiology and Celluar Biophysics at Columbia University College of Physicians and Surgeons. He teaches two undergraduate courses (Crossroads in Bioethics and Ethics for Biomedical Engineers) and one graduate course (Mechanisms of Disease). He is also the creator and faculty editor of the "Columbia University 'Journal of Bioethics.
Dr. Loike has published many ground-breaking articles on bioethics and specifically deals with bioethics from a Jewish perspective, for which he often teams with Rabbi Dr. Moshe David Tendler. His articles have dealt with such issues as stem cells, cloning, neuroethics, bioterrorism, and the interface of science and religion. Many of these issues are hotly debated around the world, and specifically in Israel, where religious leaders have a big influence in public policy. Dr. Loike has weighed in on these issues in Israeli forums, leading to policy changes there. Serving on an Rabbinical Council of America panel on stem cell research, Dr. Loike highlighted scientific innovations that could allow for additional research, while alleviating the ethical questions posed by the scientific use of embryonic stem cells.
In 1982, Loike and his longtime study partner, David Hurwitz, published a first-of-its-kind guide to Passover medications. Up until that point, no one had produced a scientific study of leaven ingredients in medications and as a result, many religious Jews had to decide on their own whether their medication could be consumed during Passover according to Jewish Law. Loike and Hurwitz painstakingly contacted various drug manufacturers to ascertain the status of their various medications. This led to a yearly publication of passover medications.
Lignans: Chemical, Biological and Clinical Properties (Chemistry and Pharmacology of Natural Products) by David C. Ayres and John D. Loike. Cambridge University Press, 2008. ISBN 978-0521065436
'"Frontiers in Bioethics" by John D. Loike and Ruth L. Fischbach, 2012;
'"'Science-based Bioethics", by John D. Loike and Ruth L. Fischbach, 2014.
'"'Science-based Bioethics", by John D. Loike and Ruth L. Fischbach, 2016.
Selected Articles
Loike, J.D. The Evolving Bioethical Landscape of Human-Animal Chimeras, in "Human Dignity in Bioethics: From Worldviews to the Public Square." (Edited by Steve Dilley and Nathan Palpant). 2013.
Loike, J. L.; Fischbach, R. L. "Ethical Challenges in Biodefense and Bioterrorism". J Bioterr Biodef. 2013: S01–S12.
Loike, J.D.; Plitt, A.; Kothari, K.; Zumeris, J.; Budhu, S.; Kavalus, K.; Ray, Y.; Jacob, H. (2013). "Surface Acoustic Waves Enhance Neutrophil Killing of Bacteria". PLOS One. 8: e68334. doi:10.1371/journal.pone.0068334.
Loike, J.D., Rush, B.S., Schweber, A., Fischbach, R. L. Lessons Learned from Undergraduate Students in Designing a Science-based Course in Bioethics, Cell Biology Education—A Journal of Life Science Education, December, 2013.
Loike, J.D. and Miller, J. Personalized Medicine, Encyclopedia of Bioethics, In Press 2013.
Loike, J.D. Tendler, M.D. Halachic Perspectives of Gestational Surrogacy, Hakirah, In Press, 2013.
Loike, J.D. Tendler (2013). "Becoming a Surrogate for an Infertile Jewish Couple". Journal of Halacha and Contemporary Society. 66: 5–21.
Margolit, Y., Levy, O., Loike, J.D., Advanced Reproductive Technologies: Reevaluating Modern Parentage, Harvard Journal of Law and Gender, in press 2013.
Loike, J.D., Hirano, M., Margalit, H., Three-Way Parenthood: dealing with the logistics of embryos created by three-parent IVF technologies that avoid the transmission of mitochondrial disease. Oct 1, The Scientist, 2013.
Loike, J.D. The Power to Predict: Using DNA Technologies to Assess the Genetics and Health of a Fetus. B’Or Ha’Torah. Jan, 2012.
Miller, J. Loike (2012). "BioCEP: A Model Educational Program for Cross-cultural Bioethics". Cambridge Quarterly of Healthcare Ethics. 21: 409–415. doi:10.1017/s0963180112000187.
Phani, S.; Loike, J.D.; Przedborski, S. (Jan 2012). "Neurodegeneration and Inflammation in Parkinson's Disease". Parkinsonism Related Disorders. 18 (Suppl 1): S207–9. doi:10.1016/s1353-8020(11)70064-5.
Arslanoglu, J.; Zaleski, S.; Loike, J.D. (2011). "An improved method of protein localization in artworks through SERS nanotag-complexed antibodies". Analytical and Bioanalytical Chemistry. 399: 2997–3010. doi:10.1007/s00216-010-4378-0.
Kothari1, K.; Zumeris, J.; Jacob, H.; Loike, J.D. (2011). "Surface Acoustic Waves cause Net Reduction in Mouse and Human Melanoma Growth in vitro. C". Columbia Undergraduate Science Journal. 5: 35–41.
Loike, J.D. Tendler (2011). "Halachic Bioethics Guidelines Journal of Halacha in Contemporary Society". Journal of Halacha in Contemporary Society. 16: 92–118.
Budhu, S.; Loike, J.D.; Constantinescu, A.; Pandolfi, A.; Clynes, R.; Silverstein, S.C. (2010). "CD8+ T-cell concentration determines the efficiency of killing of cognate antigen-expressing syngeneic mammalian cells in vitro and in vivo". Journal of Experimental Medicine. 207: 223–235. PMC 2812553 . PMID 20065066. doi:10.1084/jem.20091279.
Zhang, W.; Phillips, K.; Wielgus, A.R.; Liu, J.; Albertini, A.; Zucca, F.A.; Faust, R.; Qian, Y.; Miller, D.S.; Chignell, C.F.; Wilson, B.; Jackson-Lewis, V.; Przedborski, S.; Joset, D.; Loike, J.D.; Hong, J.; Sulzer, D.; Zecca, L. (2010). "Microglial Mac-1 is involved in phagocytosis of neuromelanin and neuronal death: implications for Parkinson's disease". Neurotoxicity Research. 19 (1): 63–72.
Arslanoglu, J. Schultz; Loike, J.D.; Peterson, K. "Immunology and Art: Using Antibody-based Techniques to Identify Proteins and Gums in Binding Media and Adhesives". J. Biosci. 35 (1): 2010.
Loike, J.D.; Gillick, M.; Prager, K.; Mayer, S.; Simon, J. Steinberg; Tendler, M.D.; Willig, M.; Fischbach, R.L. (2010). "The Critical Role of Religion: Caring for the Dying Patient from an Orthodox Jewish Perspective". Journal of Palliative Medicine. 13: 1267–1271. doi:10.1089/jpm.2010.0088.
Loike, J.D. DNA Technology: The power to detect and create. The Jewish Press pg 18, July 2, 2010.
Loike, J.D., Tendler, M.D. Ethical/Halachic Challenges Emerging From Stem Cell Research. Jewish Political Studies Review (in press Spring 2009).
Fischbach, R.L.; Loike, J. D. (2008). "Postmortem Fatherhood: Life After Life". Lancet. 371: 2166–2177. doi:10.1016/s0140-6736(08)60942-3.
Tallóczy, Z; Martinez, J; Joset, D; Ray, Y; Gácser, A; Toussi, S; Mizushima, N; Nosanchuk, JD; Nosanchuk, J; Goldstein, H; Loike, J; Sulzer, D; Santambrogio, L (2008). "Methamphetamine inhibits antigen processing, presentation, and phagocytosis". PLoS Pathog. 4: e28. PMC 2242831 . PMID 18282092. doi:10.1371/journal.ppat.0040028.
Loike, JD; Tendler, M (2008). "Reconstituting a human brain in animals: a Jewish perspective on human sanctity". Kennedy Inst Ethics J. 18: 347–67. PMID 19143409. doi:10.1353/ken.0.0269.
Loike, J.D. and Tendler, M.D. Ethical Dilemmas in Stem Cell Research: Human-Animal Chimeras. Tradition, 40:20-50, 2007.
Li, Y., Karlin, A., Loike, J.D., and Silverstein, S.C. 2004. Determination of the critical concentration of neutrophils required to block bacterial growth in tissues. J Exp Med. 200(5):613-22.
Loike, J.D.; Shabtai, D.Y.; Neuhut, R.; Malitzky, S.; Lu, E.; Husemann, J.; Goldberg, I.J.; Silverstein, S.C. (2004). "Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol". Arterioscler Thromb Vasc Biol. 24 (11): 2051–6. doi:10.1161/01.atv.0000143858.15909.29.
Wyss-Coray, T.; Loike, J.D.; Brionne, T.C.; Lu, E.; Anankov, R.; Yan, F.; Silverstein, S.C.; Husemann, J. (2003). "Adult mouse astrocytes degrade amyloid-beta in vitro and in situ". Nat Med. 9 (4): 453–7. doi:10.1038/nm838.
Loike, J.D.; Tendler, M.D. (2003). "Ma adam va-teda-ehu: halakhic criteria for defining human beings". Tradition. 37 (2): 1–19.
Husemann, J.; Loike, J.D.; Anankov, R.; Febbraio, M.; Silverstein, S.C. (Nov 2002). "Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system". Glia. 40 (2): 195–205. doi:10.1002/glia.10148.
Loike, J.D.; Tendler, M.D. (2002). "Revisiting the definition of homo sapiens". Kennedy Inst Ethics J. 12 (4): 343–50. doi:10.1353/ken.2002.0027.
Li, Y.; Karlin, A.; Loike, J.D.; Silverstein, S.C. (2002). "A critical concentration of neutrophils is required for effective bacterial killing in suspension". Proc Natl Acad Sci U S A. 99 (12): 8289–94. doi:10.1073/pnas.122244799.
Berger, M.; Budhu, S.; Lu, E.; Li, Y.; Loike, D.; Silverstein, S.C.; Loike, J.D. (2002). "Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils". J Leukoc Biol. 71 (5): 798–806.
