Species Human Entrez 3568 | Human Mouse Ensembl ENSG00000091181 | |
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Aliases IL5RA, CD125, CDw125, HSIL5R3, IL5R, Interleukin 5 receptor alpha subunit, interleukin 5 receptor subunit alpha External IDs MGI: 96558 HomoloGene: 473 GeneCards: IL5RA | ||
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.
Contents
Function
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.
Interactions
Interleukin 5 receptor alpha subunit has been shown to interact with: