Trisha Shetty (Editor)

Insulin receptor substrate

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Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.

IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.

Genes

  • IRS1 (see also Insulin receptor substrate 1)
  • IRS2 (see also Insulin receptor substrate 2)
  • IRS3P - a pseudogene
  • IRS4

    • References

    Insulin receptor substrate Wikipedia
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