In ovo is Latin for in the egg. In medical usage it refers to the growth of live virus in chicken egg embryos for vaccine development for human use, as well as an effective method for vaccination of poultry against various Avian influenza and coronaviruses. During the incubation period, the virus replicates in the cells that make up the chorioallantoic membrane.
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Advantages of In ovo method
In human vaccine development, the main advantage is rapid propagation, and high yield, of viruses for vaccine production. This method is most commonly used for growth of influenza virus, both attenuated vaccine and inactivated vaccine forms. It is recommended by the World Health Organization in managing influenza pandemics because it is high-yield and cost effective.
In poultry, In ovo vaccination improves hatchability and efficient protection against Avian influenza (AI), Newcastle disease (ND) and Coronaviruses (Av-CoV). Seroconversion rates of chickens vaccinated as embryos ranged from 27% to 100% with ND vaccination and 85% to 100% for AI vaccination. The birds are protected before delivery to a commercial operation such as a farm, thus preventing the spread of Avian viruses.
In Ovo Vaccination in Poultry
In ovo vaccination is carried out by machines. These machines perform a number of actions to ensure good vaccination of the chick inside the egg. Benefits of In ovo vaccination include avoidance of bird stress, controlled hygienic conditions, and earlier immunity with less interference from maternal antibodies.