Species Human Entrez 8660 | Human Mouse Ensembl ENSG00000185950 | |
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Aliases IRS2, IRS-2, insulin receptor substrate 2 External IDs MGI: 109334 HomoloGene: 2778 GeneCards: IRS2 | ||
Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.
Contents
Function
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Mice lacking IRS2 have a diabetic phenotype as well as a 40% reduction in brain mass.
Interactions
IRS2 has been shown to interact with:
References
IRS2 Wikipedia(Text) CC BY-SA