Entrez 8807 | Ensembl ENSG00000115607 | |
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Aliases IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein External IDs MGI: 1338888 HomoloGene: 2859 GeneCards: IL18RAP | ||
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.
Contents
Function
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.
Disease association
Variants at IL18RAP have been linked to susceptibility to Coeliac disease.
References
IL18RAP Wikipedia(Text) CC BY-SA