Species Human Entrez 3398 | Human Mouse Ensembl ENSG00000115738 | |
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Aliases ID2, GIG8, ID2A, ID2H, bHLHb26, inhibitor of DNA binding 2, HLH protein External IDs MGI: 96397 HomoloGene: 1632 GeneCards: ID2 | ||
Gene music using protein sequence of id2 inhibitor of dna binding 2 dominant negative helix loop
DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.
Contents
- Gene music using protein sequence of id2 inhibitor of dna binding 2 dominant negative helix loop
- Function
- Interactions
- References
Function
The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. A research published by "Nature" in 01/2016, authored by italian researchers Antonio Iavarone and Anna Lasorella, from Columbia University, states that ID2 protein has a relevant role in the development and resistance to therapies of glioblastoma, the most aggressive of brain cancers.
Interactions
ID2 has been shown to interact with MyoD and NEDD9.