The House of Valois-Anjou (French: Maison de Valois-Anjou, Italian: Casa Valois-Angiò) was a noble French family, deriving from the royal family, the House of Valois. They were monarchs of Naples, as well as various other territories.
The house began in the 1350s, when king John II of France, of the House of Valois line of Capetians, came to power. His paternal grandmother, Margaret, Countess of Anjou and Maine, had been a princess of the Capetian House of Anjou or Elder Angevin Dynasty. She was the eldest daughter of king Charles II of Naples and gave the county, and then duchy of Anjou to the second son of king John II of France, Louis.
Within a couple of decades, Queen Joan I of Naples, also of the senior Angevin line, realized that she would remain childless. Although there were extant heirs of the senior branch, for example, the Anjou-Durazzo cadet line, she decided to adopt Louis as her final heir.
Thus, in addition to the struggle of the Angevins with the Aragonese in Southern Italy, the two Angevin lines, senior and junior, now began to contest with each other for the possession of the Kingdom of Naples.
The Anjou-Durazzo line was initially successful in securing control of Naples, but the Valois House of Anjou managed to secure Provence and continued to contest the throne, with Louis II actually in control of the city of Naples from 1389 to 1399.
The extinction of the line of the House of Anjou-Durazzo in 1435 temporarily secured Naples for the Valois House of Anjou, but they were driven from Naples by Alfonso V of Aragon in 1442.
René, the last duke of this, third, Angevin line, died in 1480, and Anjou reverted to the French crown. With the death of his nephew the Duke of Maine in 1481 all Angevin possessions, including Provence, reverted to the crown.
The Angevin pretensions to Naples were continued intermittently by the House of Lorraine, which descended from René's eldest daughter Yolande, particularly during the Valois-Habsburg War of 1551 to 1559, when Francis, Duke of Guise, a member of a cadet branch of the family, led an unsuccessful French expedition against Naples.