EC number 3.1.3.15 ExPASy NiceZyme view | CAS number 9025-79-0 | |
In enzymology, a histidinol-phosphatase (EC 3.1.3.15) is an enzyme that catalyzes the chemical reaction
Contents
L-histidinol phosphate + H2OThus, the two substrates of this enzyme are L-histidinol phosphate and H2O, whereas its two products are L-histidinol and phosphate.
This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name of this enzyme class is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase. This enzyme participates in histidine metabolism.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2FPR, 2FPS, 2FPU, 2FPW, and 2FPX.
E. coli
In E. coli the enzyme encoded by the gene hisB is a fused imidazoleglycerol-phosphate dehydratase and histidinol-phosphatase.