Kalpana Kalpana

Helenin

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Appearance  Crystalline powder
Helenin httpsuploadwikimediaorgwikipediacommonsthu

Helenin is a phytochemical mixture found in many plant species, including the Inula helenium (elecampane) of the Asteraceae family. It is a mixture of two isomeric sesquiterpene lactones, alantolactone and isoalantolactone.

Contents

In 1895 a German scientists Julius Bredt and Wilhelm Posh extracted helenin from Inula helenium and determined its physical and chemical properties.

Properties

The roots of Inula helenium can be extracted using alcohol or other non-polar solvents to produce helenin with a composition of about 40% alantolactone and 60% isoalantolactone.

Biological activity

Alantolactone has a variety of in vitro biochemical properties, including:

  • induces apoptosis and cell cycle arrest in lung squamous cancer cells
  • suppresses STAT3 activation
  • has antiinflammatory effects by inhibiting chemokine production and STAT1 phosphorylation
  • anti-fungal
  • anti-microbial
  • Toxicity

    Certain individuals have experienced contact dermatitis when exposed to alantolactone.

    References

    Helenin Wikipedia


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