Angélique (Audrey Tautou) purchases a single pink rose at a flower shop to be delivered to her lover, Dr. Loïc Le Garrec (Samuel Le Bihan). She is a successful art student. In between creating her art projects, she works part-time at a cafe and house-sits for a wealthy vacationing family. Her friend David (Clément Sibony) disapproves of her affair with Loïc, who is married, but she insists that Loïc will leave his wife for her.
When Loïc's wife, Rachel (Isabelle Carré), has a miscarriage, the pair separate and Angélique prepares to leave with Loïc on a romantic getaway to Florence, Italy. However, Loïc doesn't meet Angélique at the airport, having chosen to mend things with his wife. This throws Angélique into a self-destructive cycle of clinical depression, losing her job and scholarship. While watching the news one night, she learns that Loïc has been arrested for assaulting one of his patients, Sonia Jasmin (Nathalie Krebs). She goes to Sonia's house to convince her to drop the charges and, in the ensuing scuffle, Sonia has a heart attack and dies. Thinking this will win Loïc back, Angélique steals from the house to make it look like a robbery. Instead, Loïc is arrested for Sonia's murder. Angélique, after witnessing Loïc embrace his wife as he is dragged away, returns home, turns on the gas oven, and lies down on the floor to die.
At this point the film rewinds to the opening scene when Angélique bought the pink rose. This time the film follows the delivery boy and the subsequent events play out from Loïc's viewpoint.
Loïc receives the pink rose and assumes that his wife sent it to him. It is revealed that Loïc barely knows Angélique and that they cross paths only because Angélique is house-sitting for Loïc and Rachel's neighbor. Loïc receives Angélique's gifts and messages, but doesn't know who sent them. It is revealed that Rachel's miscarriage was caused by "someone" running her down with a moped; earlier in the film, Angélique is shown having suffered an "accident" that ruined her friend's moped and injured her arm. Loïc comes to believe that his stalker is Sonia; he physically attacks her and she presses charges for assault. After she dies of a heart attack, Loïc is arrested as the prime suspect for her murder. At his arrest, Rachel tells the police that he was with her on the night of the death, which clears him of all charges.
That night, Loïc sees an ambulance pull up to his neighbor's house. Angélique has just tried to commit suicide. As a doctor, he performs mouth-to-mouth resuscitation, which causes her to regain consciousness. Now aware of her, he considers the possibility that she is his stalker. Exploring the house that she was house-sitting, he finds a life-sized garbage mosaic of himself. Loïc and Angélique have a final confrontation, in which he declares that they never had, nor ever will have, a relationship. Angélique strikes him over the head with a brass figurine and he falls down the stairs. Angélique is arrested, diagnosed with erotomania, and remanded to a mental institution. Rachel stands by her husband while he recovers from his injuries, and several years later the couple are shown at a house with their young children as Loïc hobbles around with a cane.
Five years after the attack, Angélique is released from the mental institution. Her therapist praises her progress and tells her, "If you keep taking your medication, you will be fine". However, when the cleaning man is clearing Angélique's room, he discovers her pills have been glued to the wall behind the wardrobe in a mosaic of Loïc, thus showing that Angélique has never taken her medication, and is still obsessed with Loïc. The film then ends with a quotation from a real erotomaniac: "Though my love is insane, my reason relieves the pain of the heart, telling me to be patient and not lose hope."
In a 2003 BBC interview, actress Audrey Tautou commented on working with director Laetitia Colombani: "I found her very precise. She knew exactly what she wanted. Even though she's very young, she managed to control the whole production. She knew her subject–this strange kind of madness–very well because she had studied it for a very long time."
The film, repeatedly compared by film critics with Amélie, received an overall very positive reaction, holding a 73% Fresh (i.e., positive) rating on Rotten Tomatoes.
In the United States, Mick LaSalle noted it was the "first feature from 26-year-old Laetitia Colombani and represents about as assured a debut as they come. The first smart thing, of many, that Colombani does is cast Audrey Tautou in the lead role. Tautou has made several movies, but in America she is known for only one, Amélie, in which she played a wide-eyed innocent. Here she is just as wide-eyed, but if she's innocent it's only by reason of insanity. He Loves Me...He Loves Me Not has its own charms, but part of its wicked kick is that it's the anti-Amélie, presenting romantic fixation, not as noble and sweet, but objectively, as something selfish and volatile....[the film is] driven by a shrewd vision and, beneath its cool French surface, a well-placed sense of moral indignation. Tautou could not be better: She's infuriating — as well as emotionally present every moment onscreen." Richard Schickel called Colombani a "terrifically assured filmmaker" whose "twice-told tale" is the "basis for an intricately ironic, darkly witty movie with a twist ending that is both utterly surprising and utterly right"; in a comparison with Tautou's performance in Amélie, the film "displays a more dangerous kind of innocence with a charm that shades off into obsessive madness in very gentle, persuasive increments. Mostly, it's because this French film brings a cool, almost Pascalian logic to the messy topic of erotomania."
In the United Kingdom, The Independent called it "an assured, if slightly too obvious thriller by first-time director Laetitia Colombani"; the film's originality in its subject matter, called a "welcome change from the offensive 'woman scorned' scenario of so many Fatal Attractions, is lost somewhat in her treatment — which gives first Angelique's perspective, before rewinding to show Loic's. But a serious plus is Tautou, whose creepy, disturbing performance proves that the wide-eyed Amélie is a young actress with range." The Evening Standard called it an "irredeemably bad French film" with "characters [that] are cartoon representations of good and evil. By the time we work out what's really going on, it's too late: Angélique has earned our hatred and Loïc has shown himself too passive to hold our interest."
In France, the film had 580,084 entrées (tickets sold); by comparison, Tautou's 2001 film Amélie, one of France's most successful films at the box office, sold 8,635,307 tickets.
The film, given a limited release to 23 North American movie theaters, grossed $1,011,102 during its theatrical run. The film was a modest success internationally grossing $101,483 in Austria, $13,306 in Czech Republic, $92,473 in Finland $720,970 in Germany, $116,274 in Hong Kong, $60,825 in Hungary, $42,151 in Poland, $25,354 in Taiwan, and $140,124 in Turkey, for a worldwide total of $5,126,264.
The original soundtrack music composed by Jérôme Coullet for He Loves Me... He Loves Me Not was released on CD in 2013 by Canadian label Disques Cinemusique. More information here.