Haloacid dehydrogenase superfamily

Updated on Feb 02, 2024

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Symbol Hydrolase_3 Pfam clan CL0137 Pfam structures		Pfam PF08282 InterPro IPR013200 PDB RCSB PDB; PDBe; PDBj

The haloacid dehydrogenase superfamily (HAD superfamily) is a superfamily of enzymes that include phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, and are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification.

Examples

A HAD domain is found in several distinct enzymes including:

Phospholipid-translocating ATPase EC 3.6.3.1, a putative lipid-flipping enzyme involved in cold tolerance in Arabidopsis

3-deoxy-D-manno-octulosonate (KDO) 8-phosphate phosphatase (EC 3.1.3.45), which catalyses the final step in the biosynthesis of KDO - a component of lipopolysaccharide in Gram-negative bacteria

Mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70), which hydrolyses mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate

Phosphoglycolate phosphatase (EC 3.1.3.18), which catalyses the dephosphorylation of 2-phosphoglycolate

Human genes encoding proteins that contain this domain include:

ATP8B3, ATP8B4, ATP10A, ATP10B, ATP10D

References

Haloacid dehydrogenase superfamily Wikipedia

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