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HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.
Contents
DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. having diverged from DRB1 approximately 4 million years ago.
DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
Associated diseases
DR52 serotype is positively associated with systemic sclerosis, inflammatory myopathies, inclusion body myositis,
DRB3*01 is positively associated with sarcoidosis, Grave's Disease, pulmonary sarcoidosis,
DRB3*0101:DRB1*0301 is linked to Lofgren's syndrome
DRB3*0202 is also linked to Grave's disease, serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, acute necrotizing encephalopathy
DRB3*0301 is weakly associated with anti-cardiolipin antibodies in SLE
DRB3*0301:DRB1*1302 may be associated with Crohn's disease
DRB1 linkage
HLA-DRB3 is linked to the following HLA-DR serotypes and DRB1 allele groups.
HLA-DR3 - DRB1*03
HLA-DR5 -
HLA-DR6 -