Structure αβ heterodimer Subtype allele | Older names A10 allele Available structures | |
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Protein transmembrane receptor/ligand Subunits HLA-A*66--, β2-microglobulin | ||
HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α66 subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus. A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.
A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele..
Serotype
A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.
References
HLA-A66 Wikipedia(Text) CC BY-SA