Species Human Entrez 9734 | Human Mouse Ensembl ENSG00000048052 | |
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Aliases HDAC9, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR, histone deacetylase 9 External IDs MGI: 1931221 HomoloGene: 128578 GeneCards: HDAC9 | ||
Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene.
Contents
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Interactions
HDAC9 has been shown to interact with: