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H 89

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Westinghouse h 89 suitcase record player


H-89 is a Protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b). H-89 blocks PKA actions through competitive inhibition of the adenosine triphosphate (ATP) site on the PKA catalytic subunit.

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H-89 and seizure

Recent study showed that using H-89 in the pentylenetetrazol-induced seizure in the wild type mice increase seizure threshold and latency.

H-89 and morphine withdrawal syndrome

The effect of H-89 (0.5, 1, 5 mg/kg) has been studied in morphine withdrawal syndrome in wild-type mice. The results indicated that H-89 significantly reduced the morphine withdrawal syndrome. In addition, results show that combination of H-89 with bucladesine as a cAMP analog has a additive attenuating effect on morphine withdrawal syndrome

References

H-89 Wikipedia


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