Guineesine (or guineensine) is an alkaloid isolated from long pepper (Piper longum) and black pepper (Piper nigrum).
Contents
Reuptake inhibition
Guineenine seems to potently inhibit the cellular reuptake of anandamide and 2-arachidonoylglycerol (EC50 = 290 nM). This causes an increase in the activity of the two neurotransmitters which are classified as endogenous cannabinoids.
Cannabimimetic effects
Guineesine can dose-dependently produce cannabimimetic effects which are indicated by potent catatonic, analgesic, hypo-locomotive and hypo-thermic effects. In addition, the analgesic and catatonic effects were reversed by the cannabinoid receptor type 1 (CB1) inverse agonist rimonabant.
Enzyme activities
Guineesine also appears to possess significant monoamine oxidase inhibitory (MAOI) effects (IC50 = 139.2 μM).
References
Guineesine Wikipedia(Text) CC BY-SA