Rahul Sharma (Editor)

Gonadotropin releasing hormone family

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Symbol
  
GnRH

InterPro
  
IPR002012

Pfam
  
structures

Pfam
  
PF00446

PROSITE
  
PDOC00432

PDB
  
RCSB PDB; PDBe; PDBj

The gonadotropin-releasing hormones (GnRH) (gonadoliberin) are a family of peptides that play a pivotal role in reproduction. The main function of GnRH is to act on the pituitary to stimulate the synthesis and secretion of luteinizing and follicle-stimulating hormones, but GnRH also acts on the brain, retina, sympathetic nervous system, gonads, and placenta in certain species. There seems to be at least three forms of GnRH. The second form is expressed in midbrain and seems to be widespread. The third form has been found so far only in fish. GnRH is a C-terminal amidated decapeptide processed from a larger precursor protein. Four of the ten residues are perfectly conserved in all species where GnRH has been sequenced.

Contents

Subfamilies

  • Gonadoliberin I InterPro: IPR004079
  • Human proteins containing this domain

    GNRH1, GNRH2

    References

    Gonadotropin-releasing hormone family Wikipedia


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